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Naloxone HCl
Poisoning/overdose
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Drug Name:

Naloxone HCl Rx

Generic Name and Formulations:
Naloxone 0.4mg/mL, 1mg/mL; IV, IM or SC inj; amps (paraben-free); vials.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Naloxone HCl:

Reversal of opioid depression, including respiratory. Diagnosis of acute opioid overdose.

Adult:

See full labeling. Post-op: 0.1–0.2mg IV, IM or SC, repeat 2–3 mins until desired response. Overdose: 0.4–2mg IV, IM or SC, repeat 2–3 mins; if no response after 10mg reevaluate. Both may require repeated doses depending on duration of narcotic activity.

Children:

See full labeling. Post-op: 0.005–0.01mg/kg IV, IM or SC, repeat 2–3 mins until desired response. Overdose: 0.01mg/kg initially; if inadequate response give 0.1mg/kg body weight. Neonates, post-op: 0.01mg/kg, repeat 2–3 mins until desired response.

Warnings/Precautions:

Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in pre-existing cardiac disease. Have other resuscitative measures available. Renal or hepatic insufficiency. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require higher naloxone dose.

Pharmacological Class:

Opioid antagonist.

Adverse Reactions:

Reversal of opioid depression: nausea, vomiting, sweating, tachycardia, increase BP, tremulousness, seizures, ventricular tacychardia and fibrillation, pulmonary edema, cardiac arrest. Also, excessive naloxone doses in post-op: reversal of analgesia, agitation.

Note:

Formerly known under the brand name Narcan.

How Supplied:

Contact supplier.

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