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MYRBETRIQ
Overactive bladder/enuresis
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Drug Name:

MYRBETRIQ Rx

Generic Name and Formulations:
Mirabegron 25mg, 50mg; ext-rel tabs.

Company:
Astellas Pharma US, Inc.

Therapeutic Use:

Indications for MYRBETRIQ:

Treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.

Adult:

Swallow whole. Initially 25mg once daily. May increase to 50mg once daily as needed or tolerated. Severe renal impairment or moderate hepatic impairment: max 25mg once daily. ESRD or severe hepatic impairment: not recommended.

Children:

Not established.

Warnings/Precautions:

Severe uncontrolled hypertension: not recommended. Monitor blood pressure periodically. Significant bladder outlet obstruction, patients taking antimuscarinic drugs for OAB: risk of urinary retention. Discontinue and treat if angioedema of the tongue, hypopharynx, or larynx occurs. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

May potentiate CYP2D6 substrates (eg, metoprolol, desipramine). Adjust dose and monitor esp. with narrow therapeutic index drugs metabolized by CYP2D6 (eg, thioridazine, flecainide, propafenone). Concomitant digoxin: use lowest digoxin dose initially (monitor and titrate).

Pharmacological Class:

Beta-3 adrenergic agonist.

Adverse Reactions:

Hypertension, nasopharyngitis, urinary tract infection, headache; angioedema.

Metabolism:

Hepatic (CYP2D6, 3A4).

Elimination:

Renal, fecal.

Generic Availability:

NO

How Supplied:

Tabs—30, 90, 100

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