Anxiety, Distress Common Among Patients With BCR-ABL-negative MPNs

Patients with PV, myelofibrosis, and other MPNs experienced significantly more distress than patients with essential thrombocythemia.
Patients with PV, myelofibrosis, and other MPNs experienced significantly more distress than patients with essential thrombocythemia.

Anxiety and distress are common among patients with BCR-ABL-negative myeloproliferative neoplasms (MPNs) and may correlate with disease-related symptom burden, according to a study published in the Journal of the National Comprehensive Cancer Network.1

To investigate the psychological manifestations among patients with BCR-ABL-negative MPNs, which include polycythemia vera, myelofibrosis, and essential thrombocythemia, researchers conducted surveys measuring anxiety, distress, and depression in 117 patients with BCR-ABL-negative MPNs. Of those, 31.2% had polycythemia vera, 28.4% had myelofibrosis, 28.4% had essential thrombocythemia, and 11.9% had another type of MPN.

MPN was diagnosed in nearly 29%, 20%, 24%, 20%, and 7.5% more than 10 years ago, 5 to 10 years ago, 3 to 5 years ago, 1 to 3 years ago, and less than 1 year ago, respectively.

Results showed that 40.4% met National Comprehensive Cancer Network (NCCN) criteria for distress and 38.5% met Hospital Anxiety and Depression Scale (HADS) criteria for distress.

In addition, 31.3% met HADS criteria for anxiety and 12.5% met HADS criteria for depression.

Investigators found that patients with polycythemia vera, myelofibrosis, and other MPNs experienced significantly more distress than patients with essential thrombocythemia (P =.016).

The study further revealed that non-white patients (P =.015) and those with polycythemia vera or myelofibrosis (P =.015) more frequently reported distress than white patients and those with essential thrombocythemia.

Additional studies are needed to determine the extent to which these psychological manifestations correspond to disease-related symptom burden in this population.

Reference

1. McFarland DC, Polizzi H, Mascarenhas J, Kremyanskaya M, Holland J, Hoffman R. Psychological symptoms among patients with BCR-ABL–negative myeloproliferative neoplasms. J Natl Compr Canc Netw. 2016;14:1563-1570.
Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs