Myelofibrosis

First Case of Dermatomyositis Associated with Secondary Myelofibrosis Following Polycythemia Vera

First Case of Dermatomyositis Associated with Secondary Myelofibrosis Following Polycythemia Vera

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A male patient with a history of polycythemia vera that converted to myelofibrosis becomes a first known case of dermatomyositis associated with secondary myelofibrosis.

JAK1, JAK2 Inhibition Improves Outcomes in Myeloproliferative Neoplasms, But More Is Needed

JAK1, JAK2 Inhibition Improves Outcomes in Myeloproliferative Neoplasms, But More Is Needed

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Myelofibrosis, extensive splenomegaly, and symptomatic burden are significantly improved for patients with MPN by JAK1 and JAK2 inhibition; however, some major needs in this patient group are still largely unmet.

Clinical Benefit of Simtuzumab Inconsistent for Myelofibrosis

Clinical Benefit of Simtuzumab Inconsistent for Myelofibrosis

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Simtuzumab is well-tolerated but has inconsistent clinical benefit for patients with myelofibrosis.

Telomerase-targeting drug demonstrates benefit in myelofibrosis treatment

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Imetelstat, a novel drug that targets telomerase, has demonstrated potential value in treating patients with myelofibrosis, according to the results of a new study.

Researchers map paths to cancer drug resistance

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The researchers have mapped the steps used by cells of melanoma, breast cancer, and the blood cancer myelofibrosis to become resistant to drugs, allowing for better success in blocking these pathways and further enabling therapies.

PRM-151 therapy well tolerated by patients with advanced myelofibrosis

PRM-151 therapy well tolerated by patients with advanced myelofibrosis

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The compound PRM-151 (PRM) has shown success in reducing progressive bone marrow fibrosis in patients with advanced myelofibrosis.

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