Multiple Myeloma

Beta-blockers May Improve Survival in Multiple Myeloma

Beta-blockers May Improve Survival in Multiple Myeloma

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Administration of beta blockers in patients with newly diagnosed multiple myeloma may be associated with a reduced risk of cancer-specific death.

Thalidomide, Lenalidomide Equivalent With Respect to Survival in Myeloma

Thalidomide, Lenalidomide Equivalent With Respect to Survival in Myeloma

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Thalidomide and lenalidomide are equivalent with respect to survival outcomes in patients with multiple myeloma.

FDA Approves Daratumumab Regimens for Relapsed Multiple Myeloma

FDA Approves Daratumumab Regimens for Relapsed Multiple Myeloma

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The US FDA has granted approval for additional indications for daratumumab for the treatment of patients with multiple myeloma who have received prior therapies.

Overall Risk of Second Primary Malignancies is Low in Multiple Myeloma

Overall Risk of Second Primary Malignancies is Low in Multiple Myeloma

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A panel of International Myeloma Working Group members  presents their review of current data on the potential host-, disease-, and treatment-related risk factors associated with the development of second primary malignancies in patients with multiple myeloma.

Vorinostat + Len-Dex Active in Lenalidomide-refractory Patients With Multiple Myeloma

Vorinostat + Len-Dex Active in Lenalidomide-refractory Patients With Multiple Myeloma

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In this single-center, open-label, phase 2b trial, researchers determined if adding vorinostat to lenadolimide and dexamethasome would improve outcomes for patients with multiple myeloma refractory to lenalidomide.

Panobinostat, Bortezomib, Thalidomide Efficacious in Relapsed Myeloma

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In this study, researchers sought to improve the safety of panobinostat plus bortezomib and dexamethasone for relapsed or relapsed and refractory multiple myeloma.

Daratumumab To Be Evaluated With Carfilzomib in Multiple Myeloma

Daratumumab To Be Evaluated With Carfilzomib in Multiple Myeloma

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Amgen talks about its collaboration with Janssen Biotech Inc on clinical trials that assess the combination of carfilzomib (Kyprolis) with daratumumab (Darzalex) in patients with multiple myeloma.

Treatment Facility Volume Associated With Mortality Risk in Multiple Myeloma

Treatment Facility Volume Associated With Mortality Risk in Multiple Myeloma

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Results of this data analysis demonstrate the relationship between treatment facility volume and all-cause mortality among patients with multiple myeloma.

Panobinostat Modestly Improves OS in Relapsed Multiple Myeloma

Panobinostat Modestly Improves OS in Relapsed Multiple Myeloma

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The phase 3 PANORAMA 1 trial previously demonstrated that panobinostat plus bortezomib and dexamethasone significantly prolonged progression-free survival vs bortezomib and dexamethasone alone. Final overall survival analysis is presented.

Daratumumab With Len-Dex Prolongs PFS in R/R Multiple Myeloma

Daratumumab With Len-Dex Prolongs PFS in R/R Multiple Myeloma

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Adding daratumumab to lenalidomide and dexamethasone significantly prolonged progression-free survival compared with lenalidomide plus dexamethasone alone in patients with relapsed or refractory multiple myeloma.

Ixazomib + Dexamethasone Active in Relapsed Multiple Myeloma

Ixazomib + Dexamethasone Active in Relapsed Multiple Myeloma

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The combination of ixazomib and dexamethasone is clinically active and well tolerated in patients with relapsed multiple myeloma not refractory to bortezomib.

Longer Maintenance Therapy Duration May Improve Survival in Myeloma

Longer Maintenance Therapy Duration May Improve Survival in Myeloma

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A longer duration of lenalidomide maintenance therapy after autologous HSCT may improve progression-free and overall survival in patients with multiple myeloma.

Ciprofloxacin May Prevent Bacteremia in Patients Undergoing Auto-HSCT

Ciprofloxacin May Prevent Bacteremia in Patients Undergoing Auto-HSCT

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Antibacterial prophylaxis with the flouroquinolone, ciprofloxacin, substantially reduced the risk of bacteremia and neutropenic fever in patients with multiple myeloma or lymphoma undergoing high-dose chemotherapy and auto-HSCT.

MRD Negativity Associated With Prolonged Survival in Myeloma

MRD Negativity Associated With Prolonged Survival in Myeloma

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Minimal residual disease (MRD) negativity after treatment is associated with prolonged overall survival in patients with newly diagnosed multiple myeloma.

Study Assesses Infection Risk With Myeloma Therapies

Study Assesses Infection Risk With Myeloma Therapies

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Researchers have determined the risk of infection for immunomodulatory drug-based therapy and proteasome inhibitor-based therapy with respect to treatment phase in patients with multiple myeloma.

Daratumumab Combo Improves PFS in Relapsed/Refractory Myeloma

Daratumumab Combo Improves PFS in Relapsed/Refractory Myeloma

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Daratumumab plus bortezomib and dexamethasone improves progression-free survival in multiple myeloma.

Daratumumab Plus Len-Dex an Encouraging Combo for Multiple Myeloma

Daratumumab Plus Len-Dex an Encouraging Combo for Multiple Myeloma

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Daratumumab plus lenalidomide and dexamethasone resulted in rapid, deep, durable responses in patients with multiple myeloma.

SES Factors Impact Survival of Younger Patients With Myeloma

SES Factors Impact Survival of Younger Patients With Myeloma

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Sociodemographic factors, not race or ethnicity, impact survival of younger patients with multiple myeloma.

Addition of Elotuzumab to Bortezomib/Dexamethasone Improves Survival in Relapsed/Refractory Multiple Myeloma

Addition of Elotuzumab to Bortezomib/Dexamethasone Improves Survival in Relapsed/Refractory Multiple Myeloma

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The addition of elotuzumab to bortezomib/dexamethasone appears to increase progression-free survival in relapsed/refractory multiple myeloma (RRMM).

Family History Not Associated With Disease Progression in MGUS

Family History Not Associated With Disease Progression in MGUS

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A family history of lymphoproliferative disorders is not a risk factor for progression from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma.

Adding Daratumumab to Lenalidomide/Dexamethasone Improves Survival in Multiple Myeloma

Adding Daratumumab to Lenalidomide/Dexamethasone Improves Survival in Multiple Myeloma

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Treatment with daratumumab, lenalidomide, and dexamethasone (DRd) may be superior to lenalidomide and dexamethasone (Rd) alone in patients with relapsed or refractory multiple myeloma.

Increasing Weight Associated With Disease Progression in Multiple Myeloma

Increasing Weight Associated With Disease Progression in Multiple Myeloma

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Increasing body mass index (BMI) allows growth and progression of disease in patients with multiple myeloma, a recently published study has shown.

Managing Treatment-related Peripheral Neuropathy in Patients with Multiple Myeloma

Managing Treatment-related Peripheral Neuropathy in Patients with Multiple Myeloma

[Blood and Lymphatic Cancer: Targets and Therapy] This research reviews clinical symptoms, diagnosis, and risk factors of peripheral neuropathy, particularly dealing with the incidence, mechanisms, and management of TiPN and BiPN.

Gene Expression Alters Bone Marrow Environment in MGUS, Leading to Multiple Myeloma

Gene Expression Alters Bone Marrow Environment in MGUS, Leading to Multiple Myeloma

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Researchers discovered that changes in the bone marrow needed for multiple myeloma to grow have already taken hold in patients with MGUS.

Assessment and Monitoring of Patients Receiving Chemotherapy for Multiple Myeloma: Strategies to Improve Outcomes

Assessment and Monitoring of Patients Receiving Chemotherapy for Multiple Myeloma: Strategies to Improve Outcomes

[Blood and Lymphatic Cancer: Targets and Therapy] This research reviews updates in the diagnosis and management of multiple myeloma, and provides for assessment and monitoring strategies for patients receiving chemotherapy for multiple myeloma.

CD38 Levels Associated With Daratumumab Response in Multiple Myeloma

CD38 Levels Associated With Daratumumab Response in Multiple Myeloma

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Response to the human CD38-directed monoclonal antibody daratumumab is significantly associated with CD38 expression on the tumor cells in patients with multiple myeloma, per a recent study.

Daratumumab in Combination With Standard-of-Care Treatment Significantly Improves Outcomes in Patients With Multiple Myeloma

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Daratumumab in combination with the standard-of-care treatment regimen reduced risk of disease progression or death by 63% compared with the standard-of-care regimen alone in patients with multiple myeloma who had received at least 1 prior line of therapy.

Carfilzomib Increases Survival for Patients With Relapsed Multiple Myeloma

Carfilzomib Increases Survival for Patients With Relapsed Multiple Myeloma

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A post-hoc analysis of the Phase 3 ASPIRE study indicates that treatment combining carfilzomib with lenalidomide and dexamethasone extended survival time for patients with multiple myeloma.

Vaccine Enters Phase I Study for Safety and Effectiveness in Multiple Myeloma

Vaccine Enters Phase I Study for Safety and Effectiveness in Multiple Myeloma

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A third clinical trial is beginning for phase I testing of SurVaxM, a cancer vaccine. This trial tests for safety and effectiveness of the vaccine in combination with lenalidomide as maintenance therapy for adults with multiple myeloma.

Daratumumab + Bortezomib/Dexamethasone: Reduced Risk of Disease Progression Seen in Relapsed or Refractory Multiple Myeloma

Daratumumab + Bortezomib/Dexamethasone: Reduced Risk of Disease Progression Seen in Relapsed or Refractory Multiple Myeloma

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Adding daratumumab to bortezomib and dexamethasone was associated with a 61% reduction in risk of disease progression in patients with relapsed or refractory multiple myeloma (RRMM), according to results of the phase 3 CASTOR study presented in a plenary session at the ASCO 2016 Annual Meeting.

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