ASCO: CAR T-Cell Therapy Promising for Multiple Myeloma

Share this content:
In this study, CAR T-cell therapy, led to 33 out of 35 patients with recurring MM to either enter full remission or experience significant cancer reduction.
In this study, CAR T-cell therapy, led to 33 out of 35 patients with recurring MM to either enter full remission or experience significant cancer reduction.

(HealthDay News) -- A new type of immunotherapy appears to provide long-lasting protection against multiple myeloma, according to the results from an early clinical trial presented at the annual meeting of the American Society of Clinical Oncology, held from June 2 to 6 in Chicago.

Wanhong Zhao, M.D., Ph.D., associate director of hematology at the Second Affiliated Hospital of Xi'an Jiaotong University in China, and colleagues re-engineered patients' T-cells and then reintroduced them to the body in three infusions performed within one week. The treatment, chimeric antigen receptor (CAR) T-cell therapy, led to 33 out of 35 patients with recurring multiple myeloma to either enter full remission or experience a significant reduction in their cancer.

To date, 19 of the first 35 Chinese patients have been followed for more than four months, the researchers report. Fourteen of those 19 patients have reached the highest level of remission. There hasn't been a relapse among any of these patients, including five followed for more than a year. Out of the remaining five patients, one experienced a partial response and four a very good response. However, 85 percent of the patients experienced cytokine release syndrome.

The research team plans to enroll a total of 100 patients in this clinical trial at four hospitals in China. "In early 2018 we also plan to launch a similar clinical trial in the United States," Zhao said in a news release from the American Society of Clinical Oncology. "Looking ahead, we would also like to explore whether B-cell maturation antigen CAR T-cell therapy benefits patients who are newly diagnosed with multiple myeloma."

The study was funded by Nanjing Legend Biotech, the Chinese firm developing the technology.

Press Release
More Information

You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs