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MOVIPREP
Constipation and bowel cleansers
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Drug Name:

MOVIPREP Rx

Generic Name and Formulations:
Polyethylene glycol 3350 200g, sodium sulfate 15g, sodium chloride 5.38g, potassium chloride 2.03g, ascorbic acid 9.4g, sodium ascorbate 11.8g; per 2L of soln; pwd for reconstitution; contains phenylalanine 131mg/treatment; lemon-flavor.

Company:
Valeant Pharmaceuticals, Inc

Therapeutic Use:

Indications for MOVIPREP:

Bowel cleansing before colonoscopy.

Adult:

No solid food from start of prep. No clear liquids at least 2hrs before colonoscopy. For both regimens start the evening before colonoscopy. Split-dose regimen: drink 240mL every 15 mins over 1hr until 1L consumed, follow with 480mL of clear liquid; in the AM, drink 2nd liter over 1hr, then drink 480mL of clear liquid at least 2hrs before colonoscopy; or, Evening-only regimen: start at least 3.5hrs before bedtime; drink 240mL every 15 mins over 1hr until 1L consumed, then drink 2nd liter 1.5hrs later over 1hr; in addition, drink 1L of clear liquid.

Children:

<18yrs: not established.

Contraindications:

GI obstruction. Bowel perforation. Gastric retention. Ileus. Toxic colitis or megacolon.

Warnings/Precautions:

Correct fluid/electrolyte abnormalities before use. History of prolonged QT, uncontrolled arrhythmias, recent MI, unstable angina, CHF, or cardiomyopathy: increased risk of arrhythmias; consider ECGs at pre-dose and post-colonoscopy. History or risk of seizures. Renal impairment; monitor baseline and post-colonoscopy electrolytes, creatinine, BUN. Inflammatory bowel disease. Rule out suspected GI obstruction/perforation before administering. Severe ulcerative colitis. Impaired gag reflex. Risk of regurgitation or aspiration. G6PD deficiency. Maintain adequate hydration. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Caution with drugs that increase risk of fluid/electrolyte abnormalities, arrhythmias or QT prolongation. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal, known or suspected hyponatremia: may increase risk of seizures. Concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Concomitant stimulant laxatives: not recommended; may increase risk of colonic ulceration, ischemic or ulcerative colitis. Oral drugs administered within 1hr of start of MoviPrep may not be absorbed.

Pharmacological Class:

Osmotic laxative.

Adverse Reactions:

Malaise, nausea, vomiting, abdominal distension and pain (give slowly or discontinue if occurs), anal discomfort, thirst, sleep disorder, rigors, hunger, dizziness; rare: arrhythmias, seizures.

Generic Availability:

NO

How Supplied:

Carton—1 (disposable container w. 4 pouches)

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