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MOTOFEN
Diarrhea
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Drug Name:

MOTOFEN CIV

Generic Name and Formulations:
Difenoxin HCl 1mg, atropine sulfate 0.025mg; tabs.

Company:
Valeant Pharmaceuticals, Inc

Therapeutic Use:

Indications for MOTOFEN:

Adjunctive therapy in the management of acute nonspecific diarrhea and acute exacerbations of chronic functional diarrhea.

Adult:

Initially 2mg, then 1mg after each loose stool or 1mg every 3–4 hours as needed. Max 8mg/24hrs. Discontinue use if no improvement after 48hrs.

Children:

Not recommended.

Contraindications:

Diarrhea associated with organisms that penetrate the intestinal mucosa (eg, toxigenic E. coli, Salmonella species, Shigella) and pseudomembranous colitis associated with broad spectrum antibiotics. Children <2yrs old. Jaundice.

Warnings/Precautions:

Monitor fluid and electrolyte balance. Withhold dose if severe dehydration or electrolyte imbalance occurs. Acute ulcerative colitis; discontinue if abdominal distention occurs or if other untoward symptoms develop. Advanced hepatorenal disease or abnormal liver function tests; hepatic coma may be precipitated. Children with Down's syndrome. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Avoid in patients in whom anticholinergic drugs are contraindicated. Hypertensive crisis possible with concomitant MAOIs. May potentiate barbiturates, tranquilizers, narcotics, alcohol; monitor.

Pharmacological Class:

Opioid + anticholinergic.

Adverse Reactions:

GI upset, dry mouth, epigastric distress, constipation, dizziness, drowsiness, headache, tiredness, nervousness, insomnia, confusion.

How Supplied:

Tabs—50, 100

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