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MINOCIN
Acne
Bacterial infections
Protozoal infections
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Drug Name:

MINOCIN Rx

Generic Name and Formulations:
Minocycline (as HCl) 50mg, 100mg; pellet-filled caps.

Company:
Bausch Health Companies Inc.

Therapeutic Use:

Indications for MINOCIN:

Adjunct in severe acne.

Adult:

Swallow whole. Take with fluids. 200mg once then 100mg every 12 hours; or 100–200mg once then 50mg four times daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Children:

≤8yrs: not recommended. Swallow whole. Take with fluids. >8yrs: 4mg/kg once then 2mg/kg (max 100mg) every 12 hours. Renal impairment (CrCl <80mL/min): max 200mg/day.

Warnings/Precautions:

Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.

See Also:

MINOCIN for INJECTION

Pharmacological Class:

Tetracycline antibiotic.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.

Adverse Reactions:

Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, skin/hypersensitivity reactions (may be severe). IV: magnesium intoxication, inj site reactions.

How Supplied:

Caps—60; Single-use vials—1, 10

Indications for MINOCIN:

Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Alternative for selected infections when penicillin is contraindicated. Anthrax due to B. anthracis.

Adult:

Swallow whole. Take with fluids. 200mg once then 100mg every 12 hours; or 100–200mg once then 50mg four times daily. Syphilis: treat for 10–15 days. Meningococcal carrier state: 100mg every 12 hours for 5 days. Mycobacterium marinum infection: 100mg every 12 hours for 6–8 weeks has been used. Uncomplicated urethral, endocervical, or rectal infection w. C.trachomatis or U. urealyticum: 100mg every 12 hours for at least 7 days. For men: Uncomplicated gonococcal infection (not urethritis or anorectal): 200mg once then 100mg every 12 hours for at least 4 days; urethritis: 100mg every 12 hours for 5 days. Renal impairment (CrCl <80mL/min): max 200mg/day.

Children:

≤8yrs: not recommended. Swallow whole. Take with fluids. >8yrs: 4mg/kg once then 2mg/kg (max 100mg) every 12 hours. Renal impairment (CrCl <80mL/min): max 200mg/day.

Warnings/Precautions:

Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.

See Also:

MINOCIN for INJECTION

Pharmacological Class:

Tetracycline antibiotic.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.

Adverse Reactions:

Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, skin/hypersensitivity reactions (may be severe). IV: magnesium intoxication, inj site reactions.

How Supplied:

Caps—60; Single-use vials—1, 10

Indications for MINOCIN:

Adjunct in acute intestinal amebiasis.

Adult:

Swallow whole. Take with fluids. 200mg once then 100mg every 12 hours; or 100–200mg once then 50mg four times daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Children:

≤8yrs: not recommended. Swallow whole. Take with fluids. >8yrs: 4mg/kg once then 2mg/kg (max 100mg) every 12 hours. Renal impairment (CrCl <80mL/min): max 200mg/day.

Warnings/Precautions:

Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.

See Also:

MINOCIN for INJECTION

Pharmacological Class:

Tetracycline antibiotic.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.

Adverse Reactions:

Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, skin/hypersensitivity reactions (may be severe). IV: magnesium intoxication, inj site reactions.

How Supplied:

Caps—60; Single-use vials—1, 10

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