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MINOCIN for INJECTION
Acne
Bacterial infections
Protozoal infections
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Drug Name:

MINOCIN for INJECTION

Generic Name and Formulations:
Minocycline 100mg; per vial; lyophilized pwd for IV infusion after reconstitution and dilution; contains magnesium sulfate heptahydrate.

Company:
The Medicines Company

Therapeutic Use:

Indications for MINOCIN for INJECTION:

Adjunct in severe acne.

Adult:

Give by IV infusion over 60 mins. Initially 200mg once, then 100mg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Children:

≤8yrs: not recommended. Give by IV infusion over 60 mins. >8yrs: Initially 4mg/kg once, then 2mg/kg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Warnings/Precautions:

Discontinue if serious dermatological reaction (eg, DRESS) or superinfection occurs. Women who are overweight or have history of intracranial hypertension. Evaluate if visual disturbance occurs. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Monitor blood, renal, and hepatic function periodically. Monitor skeletal development (esp. in children). IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

Avoid penicillins, methoxyflurane, isotretinoin. Caution with other hepatotoxic drugs. Reduced absorption with antacids containing aluminum, calcium, or magnesium and iron-containing products. May reduce effectiveness of oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. Monitor PT with oral anticoagulants. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.

See Also:

MINOCIN

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Dizziness, anorexia, nausea, vomiting, diarrhea, rash, pseudotumor cerebri, blood dyscrasias, increased BUN, interstitial nephritis, hepatotoxicity, tinnitus, tooth discoloration, hypersensitivity reactions; photosensitivity, C. difficile-associated diarrhea. IV: magnesium intoxication.

How Supplied:

Caps—60; Single-use vials—1, 10

Indications for MINOCIN for INJECTION:

Susceptible respiratory, genitourinary, skin and soft tissue, ear/nose/throat infections.

Adult:

Give by IV infusion over 60 mins. Initially 200mg once, then 100mg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Children:

≤8yrs: not recommended. Give by IV infusion over 60 mins. >8yrs: Initially 4mg/kg once, then 2mg/kg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Warnings/Precautions:

Discontinue if serious dermatological reaction (eg, DRESS) or superinfection occurs. Women who are overweight or have history of intracranial hypertension. Evaluate if visual disturbance occurs. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Monitor blood, renal, and hepatic function periodically. Monitor skeletal development (esp. in children). IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

Avoid penicillins, methoxyflurane, isotretinoin. Caution with other hepatotoxic drugs. Reduced absorption with antacids containing aluminum, calcium, or magnesium and iron-containing products. May reduce effectiveness of oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. Monitor PT with oral anticoagulants. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.

See Also:

MINOCIN

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Dizziness, anorexia, nausea, vomiting, diarrhea, rash, pseudotumor cerebri, blood dyscrasias, increased BUN, interstitial nephritis, hepatotoxicity, tinnitus, tooth discoloration, hypersensitivity reactions; photosensitivity, C. difficile-associated diarrhea. IV: magnesium intoxication.

How Supplied:

Caps—60; Single-use vials—1, 10

Indications for MINOCIN for INJECTION:

Adjunct in acute intestinal amebiasis.

Adult:

Give by IV infusion over 60 mins. Initially 200mg once, then 100mg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Children:

≤8yrs: not recommended. Give by IV infusion over 60 mins. >8yrs: Initially 4mg/kg once, then 2mg/kg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Warnings/Precautions:

Discontinue if serious dermatological reaction (eg, DRESS) or superinfection occurs. Women who are overweight or have history of intracranial hypertension. Evaluate if visual disturbance occurs. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Monitor blood, renal, and hepatic function periodically. Monitor skeletal development (esp. in children). IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

Avoid penicillins, methoxyflurane, isotretinoin. Caution with other hepatotoxic drugs. Reduced absorption with antacids containing aluminum, calcium, or magnesium and iron-containing products. May reduce effectiveness of oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. Monitor PT with oral anticoagulants. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.

See Also:

MINOCIN

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Dizziness, anorexia, nausea, vomiting, diarrhea, rash, pseudotumor cerebri, blood dyscrasias, increased BUN, interstitial nephritis, hepatotoxicity, tinnitus, tooth discoloration, hypersensitivity reactions; photosensitivity, C. difficile-associated diarrhea. IV: magnesium intoxication.

How Supplied:

Caps—60; Single-use vials—1, 10

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