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Midodrine
Hypotension
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Drug Name:

Midodrine Rx

Generic Name and Formulations:
Midodrine HCl 2.5mg, 5mg, 10mg; scored tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Midodrine:

Symptomatic orthostatic hypotension.

Adult:

Take during the day while upright; allow at least 4 hours between last dose and bedtime. 10mg 3 times daily at 3–4 hour intervals. Renal dysfunction: initially 2.5mg 3 times daily. Discontinue if no improvement after initial therapy.

Children:

Not established.

Contraindications:

Severe heart disease. Acute renal disease. Urinary retention. Pheochromocytoma. Thyrotoxicosis. Persistent, excessive supine hypertension.

Warnings/Precautions:

Initial supine systolic pressure >180mmHg: not recommended. Monitor supine and sitting BP. Discontinue if supine hypertension occurs. Diabetes. Renal or hepatic impairment. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Avoid concomitant drugs that increase BP (eg, phenylephrine, pseudoephedrine, ephedrine, dihydroergotamine, thyroid hormones, droxidopa); if unavoidable, monitor BP closely. Avoid concomitant MAO inhibitors or linezolid. Potentiated by sodium-retaining steroids (eg, fludrocortisone acetate); caution in increased intraocular pressure with fludrocortisone. Antagonized by α-antagonists (eg, prazosin, terazosin, doxazosin). Levels may be affected by renally-excreted alkaline drugs (eg, metformin, cimetidine, ranitidine, procainamide, triamterene, flecainide, quinidine). Cardiac glycosides, β-blockers, CNS drugs may cause bradycardia, AV block, arrhythmias; discontinue if bradycardia occurs.

Pharmacological Class:

Alpha-1 agonist.

Adverse Reactions:

Paresthesia, piloerection, dysuria, pruritus, supine hypertension, chills, pain, rash.

Note:

Formerly known under the brand name Proamatine.

How Supplied:

Contact supplier.

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