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Mexiletine
CHF and arrhythmias
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Drug Name:

Mexiletine Rx

Generic Name and Formulations:
Mexiletine HCl 150mg, 200mg, 250mg; caps.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Mexiletine:

Documented life-threatening ventricular arrhythmias.

Adult:

Take with food or antacid. Initially 200mg every 8hrs. Adjust dose if needed at not less than 2–3 day intervals in 50–100mg increments. Usual dose: 200–300mg every 8hrs; max 1.2g/day. If arrhythmia is controlled by ≤300mg every 8hrs, may try dividing same daily dose every 12hrs; max 450mg every 12hrs. See literature for information on rapid induction and changing from other antiarrhythmics.

Children:

Not recommended.

Contraindications:

Cardiogenic shock. 2nd- or 3rd- degree AV block unless paced.

Warnings/Precautions:

Hepatic impairment. Severe heart failure. Sinus node dysfunction or intraventricular conduction defects. Hypotension. Epilepsy. Monitor ECG, blood and liver function. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

May potentiate other antiarrhythmics, theophylline. Monitor control if used with hepatic enzyme-inducing drugs. Avoid drugs or diets that alter urinary pH.

Pharmacological Class:

Class IB antiarrhythmic.

Adverse Reactions:

GI upset, dizziness, tremor, nervousness, ataxia, chest pain, blurred vision, exacerbated arrhythmias, hepatotoxicity.

Note:

Formerly known under the brand name Mexitil.

How Supplied:

Contact supplier.

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