ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

METOPIRONE
Miscellaneous diagnostic tests
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

METOPIRONE Rx

Generic Name and Formulations:
Metyrapone 250mg; caps.

Company:
Novartis Pharmaceuticals Corp

Therapeutic Use:

Indications for METOPIRONE:

Diagnostic drug for testing hypothalamic-pituitary ACTH function.

Adult:

Single-dose short test: 30mg/kg (max 3g) at midnight with yogurt or milk. Blood sample for assay taken early the following morning. Give prophylactic dose of cortisone acetate 50mg. Multiple-dose test: Testing done over 6-day period. Administer 750mg every 4 hours for 6 doses on Day 5. See literature for results interpretation.

Children:

Single-dose short test: 30mg/kg (max 3g) at midnight with yogurt or milk. Blood sample for assay taken early the following morning. Give prophylactic dose of cortisone acetate 50mg. Multiple-dose test: Testing done over 6-day period. Administer 15mg/kg every 4 hours for 6 doses on Day 5. A minimum single dose of 250mg is recommended. See literature for results interpretation.

Contraindications:

Adrenal cortical insufficiency.

Warnings/Precautions:

May induce acute adrenal insufficiency in patients with reduced adrenal secretory capacity. Hypo- or hyperthyroidism. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Discontinue drugs affecting pituitary and adrenocortical function prior to and during testing. May be antagonized by phenytoin; test may be inaccurate in patients taking phenytoin 2 weeks prior. Subnormal response with estrogen therapy. May potentiate acetaminophen toxicity.

Pharmacological Class:

Adrenal corticosteroid synthesis inhibitor.

Adverse Reactions:

Hypotension, GI upset, abdominal pain, headache, dizziness, sedation, rash; rare: decreased WBC, bone marrow depression.

How Supplied:

Caps—18

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs