Metastasis

Atezolizumab Granted FDA Approval for Specific Cases of NSCLC

Atezolizumab Granted FDA Approval for Specific Cases of NSCLC

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Atezolizumab (Tecentriq) is approved by the FDA for the treatment of metastatic NSCLC in specific cases or tumors with EGFR or ALK gene mutations.

Outcomes in Patients With Brain Metastasis from Esophageal Carcinoma

Outcomes in Patients With Brain Metastasis from Esophageal Carcinoma

[Journal of Gastrointestinal Oncology] This research examines factors associated with survival in patients with brain metastasis from esophageal cancer.

Understanding a Molecular Switch Modulating Tumor Metastasis and Chemotherapy Resistance

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Dab2 is an endocytic adaptor and tumor suppressor whose expression occurs during the epithelial-mesenchymal transition, which is mediated by TGF-beta. This study sought to understand how Dab2 regulates apoptosis.

Metastatic Ability May Precede Tumor Formation in Pancreatic Cancer

Metastatic Ability May Precede Tumor Formation in Pancreatic Cancer

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Metastatic capabilities of pancreatic cancer might arise before tumors even form. Metastasis and advanced stage of disease at diagnosis are attributed to low survival rates for pancreatic cancer.

Dabrafenib Plus Trametinib Continue to Show Survival Benefit in BRAF-mutant Metastatic Melanoma

Dabrafenib Plus Trametinib Continue to Show Survival Benefit in BRAF-mutant Metastatic Melanoma

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The longest overall survival follow-up among randomized phase 3 trials evaluating BRAF and MEK inhibitors in patients with BRAF-mutant metastatic melanoma to date has shown the best 3-year outcome with dabrafenib plus trametinib to be in patients with normal LDH and fewer than 3 disease sites, according to a presentation at the ASCO 2016 Annual Meeting.

Palbociclib Plus Fulvestrant Provides Significant Benefit in Hormone Receptor-Positive Metastatic Breast Cancer

Palbociclib Plus Fulvestrant Provides Significant Benefit in Hormone Receptor-Positive Metastatic Breast Cancer

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ESR1 mutations detected in plasma circulating tumor DNA were identified in a high percentage of patients with hormone receptor-positive metastatic breast cancer, confirming an important role in endocrine resistance, according to an analysis of data from the phase 3 PALOMA-3 reported at the 2016 ASCO Annual Meeting.

ESR1 Mutations Predict Worse Outcome in HR-positive Metastatic Breast Cancer Treated with Aromatase Inhibitors

ESR1 Mutations Predict Worse Outcome in HR-positive Metastatic Breast Cancer Treated with Aromatase Inhibitors

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The presence of circulating ESR1 somatic mutations at disease progression in patients with HR-positive metastatic breast cancer treated with first-line AIs represent a strong and independent poor prognostic value for overall survival but no predictive value, a study presented at the 2016 ASCO Annual Meeting has found.

Tumor Shape May Affect Ability of Skin Cancer to Metastasize

Tumor Shape May Affect Ability of Skin Cancer to Metastasize

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The geometric shape of the outside edge of a cancerous tumor plays a significant role in activating tumor-seeding cells that lead to metastasis.

Low-dose Aspirin Appears to Improve Cancer Survival and Metastasis

Low-dose Aspirin Appears to Improve Cancer Survival and Metastasis

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A low-dose of aspirin could increase survival by up to 20% and help stop metastasis for patients receiving cancer treatment.

Early Study Results Show Guadecitabine Effective for Metastatic Colorectal Cancer

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A small, phase I clinical trial indicates the experimental drug guadecitabine is safe in combination with the chemotherapy drug irinotecan, and it may overcome resistance to irinotecan in patients with metastatic colorectal cancer.

Biomarker for Class 1 Uveal Melanoma Correlates with Metastatic Disease

Biomarker for Class 1 Uveal Melanoma Correlates with Metastatic Disease

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A new biomarker measurement might improve the accuracy of prognostic testing and precision medicine in uveal melanoma.

Beta Blockers Halt Progression of Aggressive Breast Cancer Cell Line

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Adrenaline acted on breast cancer cells via the cell surface beta2-adrenoceptor to promote disease growth and invasion, suggesting that beta-blockers might be helpful as adjuvant therapy for patients with aggressive breast cancer.

Adjuvant Chemotherapy More Effective in Reducing Distant Pancreatic Cancer Metastasis

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Adding radiotherapy to chemotherapy and surgery reduced the number of local disease recurrences but did not affect distant recurrences or survival.

Metastasis Increases With Elimination of Cancer-promoting Component in Breast Cancer Tumors

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Cancer metastasis is dynamically regulated by cancer-associated fibroblasts (CAFs), a cancer-promoting component in the tumor microenvironment. Eliminating the CAFs after 10 days dramatically increases the risk of the primary tumor metastasis to the lungs and bones in a mouse model.

Cancer Evolution Analyzed With a Clinically Relevant Perspective

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Current sequencing technology has enabled an analysis of cancer evolution that directs research attention away from the search for genes that enable metastasis and toward genes that are mutated early during tumorigenesis.

Overexpression of Gene in the Brain Influences Breast Cancer Metastasis

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A gene previously thought only to be expressed in the brain, GABAA receptor alpha3 (Gabra3), promotes breast cancer migration, invasion, and metastasis.

<i>PRAME</i> in Class 1 Uveal Melanoma Predicts Metastasis

PRAME in Class 1 Uveal Melanoma Predicts Metastasis

PRAME mRNA expression is independent prognostic biomarker in Class 1 uveal melanoma.

Protein on Lining of Blood Vessels Enables Breast Cancer Metastasis

Protein on Lining of Blood Vessels Enables Breast Cancer Metastasis

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The protein EPHA2, a receptor on the lining of blood vessels, controls how breast cancer cells metastasize around the body. These findings shed light on how cancer cells exit blood vessels to enter a new part of the body.

Melanoma Visualized in Live Zebrafish From Origin of First Cancer Cell To Metastasis

Melanoma Visualized in Live Zebrafish From Origin of First Cancer Cell To Metastasis

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Researchers visualized the origins of cancer from the first affected cell through its spread in a live animal: the zebrafish. This research may change scientific understanding of melanoma and other cancers leading to new treatments that can be administered before the cancer has taken hold.

Interferon Has Little Benefit for Patients With Small Amounts of Melanoma in the Lymph Nodes

Interferon Has Little Benefit for Patients With Small Amounts of Melanoma in the Lymph Nodes

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No evidence that interferon is necessary or helpful in cases of melanoma with minimal metastasis to the lymph nodes, according to the final results of the Sunbelt Melanoma Trial.

Skeletal-related Events Linked With Worse Survival, Increased Costs

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Men with prostate cancer and bone metastases that have experienced at least one skeletal-related event (SRE) show worse survival, according to a recent study.

Circulating Tumor DNA More Effective Than LDH at Detecting Metastatic Melanoma Progression, Recurrence

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Metastatic melanoma disease activity may be monitored via circulating tumor DNA, which has higher sensitivity than lactate dehydrogenase for detecting disease progression.

Drug Resistance Became Tumor Resensitization in a Unique Case of a Patient With Lung Cancer

Drug Resistance Became Tumor Resensitization in a Unique Case of a Patient With Lung Cancer

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The evolution of drug resistance in a patient with lung cancer was demonstrated in a recent case. In the case, molecular analysis of a metastatic lesion revealed resistance to a third targeted therapy; however, the new mutation restored tumor response to the first targeted therapy used.

High-Sugar Diets Increase Risks for Breast Cancer and Lung Metastases

High amounts of dietary sugar, as is common in the typical Western diet, may increase the risk of breast cancer and metastasis to the lungs.

Obesity Contributes to Metastasis in Ovarian Cancer Patients

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Obesity potently increases the potential for metastasis of ovarian cancer. A large number of studies have shown that higher body mass index is associated with a greater risk for ovarian cancer with worse overall survival.

Identifying Genetic Drivers of Breast Cancer Tumors and Metastasis

Identifying Genetic Drivers of Breast Cancer Tumors and Metastasis

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A novel genetic driver analysis of matched breast cancer primary tumors and multiorgan metastases suggests that most genetic drivers in a single tumor are based on DNA copy number variants (CNV), are established early, and are maintained in metastases. These findings were presented at the 2015 San Antonio Breast Cancer Symposium.

Mathematical Modeling Can Help Predict Impact of Surgery on Cancer Metastasis

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The size of a surgically removed tumor is generally thought to relate to the risk of metastasis; however, tumor cells metastasize at different times therefore the rate of spread is difficult to assess. A mathematical model was developed to calculate the relationship between tumor size and the relative risk of recurrence after surgery.

Model Uses Nonclinical Calculations to Forecast the Metastasis Path of Breast Cancer

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Researchers developed a mathematical model to forecast metastatic breast cancer survival rates using techniques usually reserved for weather prediction, financial forecasting, and surfing the Web.

Tumors May Seed Cancer Metastases Earlier Than Expected

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A new study has found an additional mechanism explaining how EGFR, a molecule long linked to cancer progression appears, to seed the body with metastatic cells long before doctors would typically detect a primary tumor.

Oxidative Stress Inhibits Melanoma Cell Metastasis

Oxidative Stress Inhibits Melanoma Cell Metastasis

Metastasizing cells undergo metabolic changes, increasing their ability to withstand oxidative stress.

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