Metastases

Race Does Not Predict Prostate Cancer Metastasis Development

Race Does Not Predict Prostate Cancer Metastasis Development

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Race is not associated with the development of metastases in patients with nonmetastatic castration-resistant prostate cancer (CRPC), according to a recently published study.

Survival Is Better With SRS Than With WBRT for NSCLC or Breast Cancer Metastases to the Brain

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Longer survival was achieved with stereotactic radiosurgery (SRS) alone than with whole-brain radiation therapy (WBRT) in patients with fewer than 4 brain metastases from NSCLC or breast cancer.

Resection of Abdominal Melanoma Metastases More Than Doubles Patient Survival Time

Patients with melanoma who undergo surgical resection of abdominal metastases live more than twice as long as those treated with drug therapy alone, according to novel research presented at the American College of Surgeons Clinical Congress 2015.

Genetic Profiles of Brain Metastases Differ From Those of Primary Tumors

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A new study finds that, while brain metastases share some genetic characteristics with the primary tumors from which they originated, they also carry unique genetic mutations, indicating that the evolutionary pathways of the metastatic and the primary tumors have diverged, which may change sensitivities to targeted therapy drugs.

Metastatic Breast Cancer Cells Activate Stem Cell Genes

Metastatic Breast Cancer Cells Activate Stem Cell Genes

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Metastases cause the vast majority of cancer deaths, but their tiny seeds are so difficult to track. Now, scientists described studying individual metastatic cells from human breast cancer tumors implanted into mice as the cells escaped into the blood stream and began to form tumors elsewhere in the body.

Blood test detects breast cancer metastasis early

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A blood test that involves examination of cell-free circulating DNA could be key to earlier detection of breast cancer metastases.

Addition of SIRT Fails to Improve Overall Progression-free Survival in Colorectal Cancer Liver Metastases

Addition of SIRT Fails to Improve Overall Progression-free Survival in Colorectal Cancer Liver Metastases

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Addition of selective internal radiation therapy (SIRT) failed to improve progression-free survival in non-resectable colorectal cancer liver metastases.

RFA Plus Chemo Associated with Improved Survival in Unresectable Colorectal CA Liver Metastases

RFA Plus Chemo Associated with Improved Survival in Unresectable Colorectal CA Liver Metastases

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A combination of radiofrequency ablation and systemic chemotherapy was associated with improved long-term overall survival in patients with unresectable colorectal cancer liver metastases, according to data presented at the 2015 American Society of Clinical Oncology annual meeting.

Enoxaparin may be safe for patients with cancer, brain metastases

Enoxaparin may be safe for patients with cancer, brain metastases

Patients with cancer and brain metastases who develop blood clots may safely receive enoxaparin.

Immune checkpoint inhibitors may work in brain cancers

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New evidence indicates that immune checkpoint inhibitors may work in glioblastoma and brain metastases.

Five myths may compromise care of patients with brain metastases

Five myths may compromise care of patients with brain metastases

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A blue-ribbon team of national experts on brain cancer said that professional pessimism and out-of-date myths rather than current science may compromise the care of patients with cancer that has metastasized to the brain.

Survival improved by stereotactic radiosurgery alone in adults under 50 years with limited brain metastases

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Overall survival was improved for adults age 50 years and younger with brain cancer who were treated with stereotactic radiosurgery that was not combined with whole-brain radiotherapy.

MicroRNA-31 might predict lung cancer spread to lymph nodes

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Measuring levels of the molecule microRNA-31 might accurately determine if a patient's lung cancer has spread to nearby lymph nodes.

ATF3 key role in breast cancer metastasis

ATF3 key role in breast cancer metastasis

ATF3 expression in stromal mononuclear cells correlates with clinical outcomes and predicts death.

New therapy strategy for breast cancer that has spread to the brain

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Cellular therapy and gene therapy have been successfully combined in a mouse model to develop a viable treatment strategy for breast cancer that has spread to a patient's brain.

Breast cancer cell defects linked with lymph node metastases

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Breast tumors that carry breast cancer stem and progenitor cells with mutations in specific oncogenes are significantly more likely than other breast cancers to metastasize to the lymph nodes, researchers reported.

Ovarian cancer metastases influenced by factors in target tissues

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Both milky spots and fat cells in the omentum promote cancer cell migration, growth, and spread, reports new research. Results from a series of experiments have suggested a two-step model of omental colonization.

Breast cancer prognosis more accurate when lymph nodes examined

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After a breast cancer operation, the removed tumor is always examined, as its subtype can provide an indication of how aggressive the disease is.

Serum <i>miR-21</i> a potential colorectal cancer biomarker

Serum miR-21 a potential colorectal cancer biomarker

MicroRNA levels were increased in serum from patients with adenoma, CRC; but drop after curative surgery.

Antibody therapy helps immune system fight tumors

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Regulatory T (Treg) cells that infiltrate tumors express proteins that can serve as targets for therapeutic antibodies, suggesting that treatments aimed at these immune cells could be a promising approach in cancer treatment.

How dormant breast cancer tumor cells become metastatic

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The long-standing mystery about what activates dormant disseminated breast cancer tumor cells after years and even decades of latency may have been solved.

Survival improved by surgery and radiation for patients with metastatic gastric cancer

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Recently, researchers analyzed metastatic gastric cancer cases from the SEER database to help determine which treatment options offer the best survival possibilities.

Spine metastases can be controlled with tumor separation surgery and high-dose SRS

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Tumor separation surgery followed by high-dose hypofractionated stereotactic radiosurgery (SRS) or high-dose single-fraction SRS is safe and effective in controlling spinal metastases regardless of the radiosensitivity of the particular tumor type that has invaded the spine.

Some breast cancers may respond to anti-androgen drug

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Newly approved for prostate cancer, enzalutamide may be useful as a therapeutic agent in breast cancer that evades other treatments.

Annual report highlights 2012 cancer advances

The American Society of Clinical Oncology has released a nearly 100-page report detailing the year's most significant developments in cancer.

Regorafenib prolongs survival in face of GI cancers

Persons with metastatic colorectal cancer or gastrointestinal stromal tumors may garner some survival benefit from regorafenib after standard treatments have failed.

Higher fulvestrant doses prolonged survival in patients with advanced breast cancer

Increasing the dose of fulvestrant from 250 mg to 500 mg improved median overall survival in women with locally advanced or metastatic estrogen receptor-positive breast cancer, according to updated data from the CONFIRM trial.

Suppressed protein halted melanoma metastasis

Inhibiting one protein eliminated metastasis of melanoma in lab studies, a finding that could lead to targeted therapies for a range of cancers.

Denosumab extended survival in lung cancer with bone metastases

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Denosumab improved overall survival in persons with lung cancer and bone metastases more effectively than did zoledronic acid.

New treatment on horizon offers hope for metastatic melanoma patients

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Treatment combining electroporation and the drug DNA IL-12 has yielded preliminary positive results in response to treatment and safety among patients with metastatic melanoma.

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