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MENEST
Menopause and HRT
Prostate and other male cancers
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Drug Name:

MENEST Rx

Generic Name and Formulations:
Esterified estrogens 0.3mg, 0.625mg, 1.25mg, 2.5mg; tabs.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for MENEST:

Moderate to severe vasomotor symptoms of menopause. Atrophic vaginitis. Kraurosis vulvae. Hypoestrogenism.

Adult:

Menopause: 1.25mg daily, give cyclically (3 weeks on, 1week off); if menstruating use Day 5 start. Atrophic vaginitis, kraurosis vulvae: 0.3–1.25mg or more daily, give cyclically (3 weeks on, 1 week off). Hypogonadism: 2.5–7.5mg daily in divided doses for 20 days then stop for 10 days; repeat course if withdrawal bleeding does not occur within these 10 days. If bleeding occurs within 10 days, begin 20-day cyclic regimen adding an oral progestin. If bleeding occurs before this regimen is finished, discontinue therapy and may resume on Day 5 of bleeding. Female castration, primary ovarian failure: 1.25mg daily, cyclically. Reevaluate periodically.

Children:

Not applicable.

Contraindications:

Thrombophlebitis. Thromboembolic disorders. Cerebrovascular or coronary artery disease. Pregnancy (Cat.X).

Warnings/Precautions:

Hepatic dysfunction. Gallbladder disease. Conditions aggravated by fluid retention. Familial hyperlipoproteinemia. Discontinue if jaundice occurs. Nursing mothers.

Pharmacological Class:

Estrogen.

Adverse Reactions:

See literature. Breakthrough bleeding, dysmenorrhea, mastodynia, migraine, depression, edema, weight changes, hypertension, GI upset.

How Supplied:

Tabs 2.5mg—50; 0.3mg, 0.625mg, 1.25mg—100

Indications for MENEST:

Palliative treatment of androgen-dependent advanced prostate cancer.

Adult:

1.25–2.5mg 3 times daily.

Children:

Not applicable.

Contraindications:

Thrombophlebitis. Thromboembolic disorders. Cerebrovascular or coronary artery disease. Pregnancy (Cat.X).

Warnings/Precautions:

Hepatic dysfunction. Gallbladder disease. Conditions aggravated by fluid retention. Familial hyperlipoproteinemia. Discontinue if jaundice occurs. Nursing mothers.

Pharmacological Class:

Estrogen.

Adverse Reactions:

See literature. Migraine, depression, edema, weight changes, hypertension, GI upset, gynecomastia, impotence.

How Supplied:

Tabs 2.5mg—50; 0.3mg, 0.625mg, 1.25mg—100

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