Melanoma

Patient Interest in Melanoma Genetic Risk Testing is Fairly High

Patient Interest in Melanoma Genetic Risk Testing is Fairly High

Researchers examined interest in MC1R testing in the general population and assessed patterns across demographic and skin cancer risk factors.

Study Finds Association Between Folate Intake and Risk of Cutaneous Melanoma

Study Finds Association Between Folate Intake and Risk of Cutaneous Melanoma

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Researchers assessed the effect intake levels of folate and other nutrients involved in one-carbon metabolism have on risk of melanoma.

Melanoma Outcomes Improved With Nivolumab Alone or Plus Ipilimumab

Melanoma Outcomes Improved With Nivolumab Alone or Plus Ipilimumab

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Systemic review and meta-analysis evaluated the efficacy of nivolumab vs ipilimumab, in combination, as monotherapy, or vs other treatment options for the treatment of metastatic melanoma.

Oral Contraceptive Use May Not Be Associated With Increased Melanoma Risk

Oral Contraceptive Use May Not Be Associated With Increased Melanoma Risk

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Researchers sought to determine if melanoma risk was associated with oral contraceptive use or if OC users are more likely to have higher exposure to UV light.

Encorafenib, Binimetinib Combination Receives FDA Approval for Mutation-Positive Melanoma

Encorafenib, Binimetinib Combination Receives FDA Approval for Mutation-Positive Melanoma

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Approval was granted for the treatment of patients with unresectable or metastatic BRAF V600E or V600K mutation-positive melanoma.

Radiation, Immunotherapy Improved Median Overall Survival in Melanoma Brain Metastases

Radiation, Immunotherapy Improved Median Overall Survival in Melanoma Brain Metastases

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Study data indicate that checkpoint inhibitors combined with radiation could improve survival for patients with melanoma-related brain metastases.

New Guidelines Increase Melanoma Staging Reproducibility and Concordance

New Guidelines Increase Melanoma Staging Reproducibility and Concordance

Greater reproducibility and higher concordance for melanoma staging observed with implementation of AJCC 8.

Link Found Between Skin Cancer Risk and High Polyunsaturated Fat Intake

Link Found Between Skin Cancer Risk and High Polyunsaturated Fat Intake

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Using data from the NHS and the HPFS, researchers investigated the association between polyunsaturated fat, cholesterol, and monounsaturated fat intake and risks for SCC, melanoma, and BCC.

Lower Risk for Alzheimer Associated With Skin Cancer Diagnoses

Lower Risk for Alzheimer Associated With Skin Cancer Diagnoses

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After adjusting for confounding factors,a significantly decreased risk for subsequent AD was reported among patients with malignant melanoma.

Durable Response Achieved With Nivolumab in Untreated Melanoma Brain Metastases

Durable Response Achieved With Nivolumab in Untreated Melanoma Brain Metastases

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In this phase 2 study, researchers randomly assigned 79 patients with immunotherapy-naive melanoma with brain metastases to receive either nivolumab plus ipilimumab or nivolumab alone.

Study Determined Association Between Risk of Melanoma, Aspirin Use

Study Determined Association Between Risk of Melanoma, Aspirin Use

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In a review of nearly 200,000 patients from a Midwest metropolitan area, researchers sought to determine if chronic aspirin use would offer the same risk reduction for melanoma as has been seen in various cancers.

Hope, Optimism Reduce Psychological Distress in Advanced Cancer

Hope, Optimism Reduce Psychological Distress in Advanced Cancer

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A cross-sectional analysis evaluated the impact of hope and optimism on different facets of psychological distress among patients with advanced melanoma, colorectal, lung, or gastrointestinal cancers.

Prognostic Indicator for Cutaneous Melanoma: SNLB vs Breslow Thickness

Prognostic Indicator for Cutaneous Melanoma: SNLB vs Breslow Thickness

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Investigators sought to compare the prognostic value of sentinel lymph node status vs Breslow thickness in patients with cutaneous melanoma.

Presence of Iris Pigmented Lesions Indicates Melanoma Risk

Presence of Iris Pigmented Lesions Indicates Melanoma Risk

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The likelihood for development of cutaneous melanoma may be greater for individuals with iris pigmented lesions, according to a study.

Age Not a Deterrent to Immunotherapy for Malignant Melanoma

Age Not a Deterrent to Immunotherapy for Malignant Melanoma

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Investigators sought to evaluate whether age is associated with risk for immune-related adverse events among patients with metastatic melanoma treated with immunotherapy.

Adjuvant Vemurafenib Does Not Improve Disease-Free Survival in Melanoma

Adjuvant Vemurafenib Does Not Improve Disease-Free Survival in Melanoma

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Researchers report on finding of a double-blind phase 3 study on the efficacy of adjuvant vemurafenib in patients with resected stage IIC to IIIB melanoma.

Induced Pluripotent Stem Cell Vaccine May Help Prevent Tumor Growth

Induced Pluripotent Stem Cell Vaccine May Help Prevent Tumor Growth

iPSC vaccine prevented tumor growth in syngeneic murine breast CA, mesothelioma, melanoma models

Obesity, Male Gender May Improve Survival Outcomes with Targeted and Immunotherapy in Melanoma

Obesity, Male Gender May Improve Survival Outcomes with Targeted and Immunotherapy in Melanoma

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A retrospective study evaluated the relationship of BMI with survival outcomes among patients with metastatic melanoma who received targeted therapy, immunotherapy, or chemotherapy.

FDA Upgrades Nivolumab to Regular Approval for Adjuvant Treatment of Advanced Melanoma

FDA Upgrades Nivolumab to Regular Approval for Adjuvant Treatment of Advanced Melanoma

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The FDA granted approval for nivolumab for adjuvant treatment of some patients with melanoma, based on the results of the CHECKMATE-238 study.

Potential for Metastatic Melanoma Cure Seen in High CR Rate With Pembrolizumab

Potential for Metastatic Melanoma Cure Seen in High CR Rate With Pembrolizumab

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Baseline tumor size and PD-L1 status were independently associated with the likelihood of a complete response.

Distinct Patterns of Shiny White Streaks Strong Indicator of Melanoma

Distinct Patterns of Shiny White Streaks Strong Indicator of Melanoma

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Patients presenting with lesions with shiny white streaks on dermoscopy should undergo biopsy for possible melanoma.

Melatonin Derivatives Exhibit Cytotoxic Activity in Melanoma and Breast Cancer

Melatonin Derivatives Exhibit Cytotoxic Activity in Melanoma and Breast Cancer

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Melatonin and its analogues, in addition to their ability to regulate circadian rhythms, may exhibit cytotoxic activity via various cellular mechanisms.

No Increased Risk for Melanoma in Patients With MM

No Increased Risk for Melanoma in Patients With MM

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An increased prevalence of melanoma has been observed in patients with various immunocompromised conditions.

Researchers Find No Link Between Acne and Malignant Melanoma in Men

Researchers Find No Link Between Acne and Malignant Melanoma in Men

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Individuals categorized as overweight or obese had a significantly increased risk for malignant melanoma.

Survival Benefit in Advanced Melanoma With Pembrolizumab Versus Ipilimumab

Survival Benefit in Advanced Melanoma With Pembrolizumab Versus Ipilimumab

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Fifty-five percent of patients treated with pembrolizumab survived through 24-months compared with 43% of patients treated with ipilimumab.

Challenging the Standard of Care in Advanced Melanoma: Focus on Pembrolizumab

Challenging the Standard of Care in Advanced Melanoma: Focus on Pembrolizumab

[Cancer Management and Research] This study examines the advances that pembrolizumab has made in melanoma and upcoming research that may further improve melanoma treatment.

Case Report of a KIT-mutated Melanoma Patient With an Excellent Response to Apatinib and Temozolomide Combination Therapy

Case Report of a KIT-mutated Melanoma Patient With an Excellent Response to Apatinib and Temozolomide Combination Therapy

[OncoTargets and Therapy] This article examines a case of metastatic melanoma in which the patient had an excellent response to apatinib/TMZ combination therapy with progression-free survival for more than one year.

Overall Survival Increase for Melanoma Brain Metastases

Overall Survival Increase for Melanoma Brain Metastases

Median overall survival from time of diagnosis has increased from 7.5 to 22.7 months in the last decade.

Overall Survival in Advanced Melanoma Improved With Nivolumab, Ipilimumab Combination

Overall Survival in Advanced Melanoma Improved With Nivolumab, Ipilimumab Combination

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Overall survival was significantly prolonged in patients with advanced melanoma who were treated with nivolumab plus ipilimumab compared with either drug alone, according to results from the Checkmate 067 study.

Risk of Some Cancers Higher in Women With a History of Periodontal Disease

Risk of Some Cancers Higher in Women With a History of Periodontal Disease

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A study on a cohort of women enrolled in the WHI-OS shows that those with a history of periodontal disease had a higher risk for developing some cancers.

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