Prognosis Poor for Women With Pregnancy-Associated Melanoma

This article originally appeared here.
Poor Prognosis for Women With Pregnancy-Associated Melanoma
Poor Prognosis for Women With Pregnancy-Associated Melanoma

(HealthDay News) -- For women aged younger than 50 years, melanoma prognosis is worse for those aged 40 to 49 years and for those diagnosed with a pregnancy-associated melanoma, according to a study published in the April issue of the Journal of the American Academy of Dermatology.

Alejandra Tellez, M.D., from the Cleveland Clinic, and colleagues conducted a retrospective study to examine histopathology, staging, risk factors, and outcomes of cutaneous melanoma in women aged up to 49 years with biopsy-proven melanoma.

The researchers identified 462 patients with cutaneous melanoma (mean age, 34.7 years). Women aged 19 years or younger less frequently had invasive melanoma (P < 0.0008). Women aged 40 to 49 years had higher positive sentinel node status (P < 0.008), recurrence rates, metastatic disease (P < 0.001), and death rates (P < 0.008). Significantly worse prognosis was seen for the 41 women with a pregnancy-associated melanoma compared with control non-pregnant patients, with nine-, seven-, and five-fold increases in recurrence (P < 0.001), metastasis (P = 0.03), and mortality (P = 0.06), respectively.

"The increasing incidence of melanoma for women younger than 50 years suggests that regular skin checks and self-examinations are warranted," the authors write. "In addition, in women given the diagnosis of melanoma during or within one year after childbirth, regular follow-up and monitoring for recurrence are recommended."

Full Text (subscription or payment may be required)

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs