The FDA approved the indication expansion for ipilimumab based on evidence from 2 clinical trials evaluating its safety and efficacy in pediatric patients.
When researchers sent sample slides to pathologists for review, the assessments varied widely and some pathologists even disagreed with their own initial assessment when retested months later.
Five-year survival rate found similar to observation despite a significant improvement in disease-free interval.
Study of patients with resected high-risk melanoma reveals higher rates of treatment-related adverse events with 10 vs 3 mg/kg.
'Conquer Fear' decreased fear among survivors of breast and colorectal cancer and melanoma compared with relaxation techniques.
Biopolymer codelivery of CAR T cells and stimulator of IFN genes directly to the surface of solid tumors more effectively reduced tumor size.
Two-gene pigmented lesion test classifies skin lesions as melanoma or nonmelanoma, helping with diagnostic challenges faced with the visual image and pattern recognition approach.
Dermatologist assessment of screening practices addresses the lack of a national consensus on screening guidelines for melanoma.
Patients with psoriasis had 1.53 times greater risk of developing a malignancy, regardless of the type of psoriasis therapy they are receiving.
Whole-exome sequencing of tumor biopsies explain low response rate to immunotherapy in metastatic melanoma.
Despite their efficacy in metastatic melanoma, KIs include risk of serious side effects in patients. This overview explains the effects and management recommendations for 4 agents used to treat metastatic melanoma.
Rechallenge with dabrafenib plus trametinib demonstrated antitumor activity in patients who had previously progressed on BRAF inhibitor therapy.
Rosiglitazone has potential for older patients with melanoma who develop resistance to targeted therapies.
Researchers sought to conduct a cost-effectiveness analysis of immunotherapy for patients with advanced melanoma.
Clinical trials show pembrolizumab active against mucosal melanoma, extends survival in bladder cancer.
Using statistical models, predictions were made for death rates from melanoma in 3 three countries and based on availability of a treatment.
Researchers compared the ability of an artificial-intelligence algorithm to recognize and classify skin cancers with the clinical evaluations of dermatologists.
Induction therapy with intravenous interferon α-2b appeared to be no better than observation alone for the management of patients with intermediate-risk melanoma.
Results of a series of Internet surveys revealed customers' perceptions of harms, benefits, and limitations of genetic information received from direct-to-consumer genetic testing.
Comparison studied the effectiveness of sun protection offered by a beach umbrella alone with that of sunscreen with a high sun protection factor.
Melanoma incidence varies by region, and many states have experienced an increase.
A review of data from three large, prospective studies examined a potential association between alcoholic beverage consumption and risk of melanoma.
Despite the effectiveness of dabrafenib in combination with trametinib for metastatic BRAF-mutant melanoma, many patients experience disease progression that often leads to death. In this data analysis, researcher sought to identify clinical factors associated with long-term response and survival.
Atlhough survival for patients with advanced melanoma is similar with both targeted therapies and immunotherapies, a review of the literature reveals why one of them may be a better choice as first-line therapy.
Neurotoxicity is not uncommon in patients with melanoma treated with immune checkpoint inhibitors. In this study, therefore, researchers sought to examine the incidence of neurotoxicity across anti-CTLA-4 and anti-PD-1 antibodies at a single institution.
More melanomas are self-detected by women; men tend to have more melanomas in less visible locations.
A newly developed, evidence-based psychoeducational intervention effectively reduced fear of cancer recurrence and stress in patients at high risk for developing another melanoma.
Treatment with pembrolizumab better maintained health-related quality of life compared with chemotherapy in patients with advanced melanoma refractory to ipilimumab.
Pevonedistat was effective for inhibiting proliferation of melanoma cell lines in vitro, research indicates.
Patients with localized melanoma see their supportive care needs peak at their initial cancer diagnosis and if they experience disease recurrence.
Response rates with PD-1 inhibitors in patients with acral and mucosal melanomas were similar to previously reported rates in patients with cutaneous melanoma.
Variants of the MC1R gene, associated with red hair, pale skin, and freckles, increases the number of genetic mutations related to skin cancer and the level of other gene mutations, further increasing the risk for skin cancer.
Cobimetinib in combination with vemurafenib as a standard first-line approach improves survival in patients with BRAF V600 mutation-positive melanoma, updated results of the coBRIM study.
New report doesn't change Task Force's prior statement on skin cancer screening issued in 2009
Training Primary Care Providers to Screen for Melanoma Increases Diagnoses, With Little Affect on Dermatology Visits or Skin Surgeries
Training primary care providers (PCP) to detect early melanoma led to increased melanoma diagnoses, but had little impact on skin surgeries or dermatology visits.
The Melanoma MAICare Framework: A Microsimulation Model for the Assessment of Individualized Cancer Care
[Cancer Informatics] In this research, a microsimulation model framework is used to examine the impact of simultaneously altering curative treatment approaches in different phases of melanoma treatment.
Patients receiving PD-1 or PD-L1 antibodies exhibited papular and nodular eruptions with scale, as well as mucosal lesions with lichenoid features, that were typically manageable with topical steroid treatment.
De novo melanomas, which arise from clinically normal skin with no associated nevus, may be more aggressive than nevus-associated melanomas.
In addition to improving overall survival compared with dacarbazine in patients with advanced melanoma, nivolumab maintains baseline levels of health-related quality of life to ultimately confer long-term quality of survival benefit.
Population-based screening for melanoma performed by primary care providers does not cause substantial harm with respect to skin surgeries and dermatology visits.
PEG-IFN did not improve improve outcomes for patients with melanoma compared with IFN. Furthermore, patients receiving PEG-IFN were more likely to discontinue treatment due to toxicity.
Disease-Free Status Is Achieved by Combining Immunotherapy Treatments in Patient With Metastatic Melanoma
A patient with refractory metastatic melanoma was successfully treated with a novel combination of 2 different types of immunotherapy.
Cutaneous melanoma is rare on feet, but often advanced at point of diagnosis.
Pembrolizumab provides benefit over ipilimumab in patients with advanced melanoma, regardless of tumor PD-L1 expression status or number of prior therapies, a study presented at the 2016 ASCO Annual Meeting has shown.
A newly discovered synthesized drug reduced the viability of melanoma cells without affecting normal cells in cell culture and mouse xenograft models of the disease. The drug, HA15, is a type of thiazole benzenesulfonamide.
Final analysis of data from the phase 3 KEYNOTE-006 presented at the ASCO 2016 Annual Meeting confirm the superiority of pembrolizumab over ipilimumab for advanced melanoma.
At 3 years, 40% of patients with advanced melanoma treated with pembrolizumab are alive regardless of whether they had been treated with ipilimumab or not, follow-up results from the KEYNOTE-001 study reported at the ASCO 2016 Annual Meeting.
The longest overall survival follow-up among randomized phase 3 trials evaluating BRAF and MEK inhibitors in patients with BRAF-mutant metastatic melanoma to date has shown the best 3-year outcome with dabrafenib plus trametinib to be in patients with normal LDH and fewer than 3 disease sites, according to a presentation at the ASCO 2016 Annual Meeting.
Binimetinib may represent a new effective therapy for patients with NRAS-mutant melanoma, both before and after immunotherapy. That is the conclusion of the phase 3 NEMO study, results of which were presented at the ASCO 2016 Annual Meeting.
Four in 10 patients with newly diagnosed and previously treated advanced melanoma were alive 3 years after initiating pembrolizumab.
Combining radiation treatments with a new generation of immunotherapies is showing promise in the treatment of melanoma, according to a recent review.
Plasma from a blood draw can be used to test for BRAF V600 mutations in advanced cancers in just 90 minutes, and results were comparable to using tissue biopsy.
Abemaciclib, an investigational cancer therapeutic, showed durable clinical activity as a continuous single-agent therapy, according to results of a phase 1 trial with 5 tumor-specific cohorts.
The Bim protein might predict which patients could be successfully treated with immunotherapy for metastatic melanoma.
New study highlights the importance of diagnosing and treating obstructive sleep apnea because of possible cancer connection.
[Cancer Control] This research explores the efficacy of intralesional therapy as a treatment option for patients with unresectable, locally advanced, or metastatic melanoma.
Overall objective responses occurred in one-third of patients with melanoma who were treated with pembrolizumab in a phase 1b clinical trial.
Melanoma onset was delayed by applying sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet-B light in a mouse model of the disease.
Among patients with advanced melanoma, the human PD-1-blocking antibody pembrolizumab was associated with an overall objective response rate of 33%, 12-month progression-free survival rate of 35%, and median overall survival of 23 months.
Therapy for the elderly with melanoma may be affected by findings that aged tumor cells in melanoma behave differently than younger tumor cells.
Though sunbathers are at an increased risk of developing skin cancer, women who sunbathe are likely to live longer than those who avoid the sun.
Microneedles embedded in a patch deliver cancer immunotherapy treatment directly to the site of melanoma, according to preliminary findings in animal studies.
Variant of gene linked to skin pigmentation may be tied to higher melanoma risk.
Physicians shouldn't rely on mole count as the only reason to perform skin exams for melanoma.
The expression of the PAX3 and MITF genes in melanoma can cause early, nonmutational, reversible drug resistance; tissues that express these genes can then later develop mutational, irreversible drug resistance. The HIV drug nelfinavir can prevent this resistance.
Among women aged up to 49 years with a pregnancy-associated melanoma, recurrence rates were higher than seen in other groups.
Anti-programmed cell death-1 therapy tied to lichenoid reactions, eczema, vitiligo
A new biomarker measurement might improve the accuracy of prognostic testing and precision medicine in uveal melanoma.
RECIST v1.1 may underestimate the treatment response in patients with advanced melanoma treated with pembrolizumab.
Among younger patients, thick melanomas may be commonly found in those with fewer total nevi but more atypical nevi.
PRAME mRNA expression is independent prognostic biomarker in Class 1 uveal melanoma.
Researchers visualized the origins of cancer from the first affected cell through its spread in a live animal: the zebrafish. This research may change scientific understanding of melanoma and other cancers leading to new treatments that can be administered before the cancer has taken hold.
No evidence that interferon is necessary or helpful in cases of melanoma with minimal metastasis to the lymph nodes, according to the final results of the Sunbelt Melanoma Trial.
Patients with advanced cancer view life goals as distinct from and less important than treatment goals, according to a recent study.
Earlier and More Frequent Tanning Bed Use by Women Associated With Melanoma Incidence and Age at Diagnosis
Younger age at first use and more frequent use of indoor tanning beds are largely responsible for the steep increase in melanoma diagnoses in women younger than 40 years.
Prognosis for patients with cutaneous melanoma may be predicted by an inherited genetic marker providing a personalized tool to gauge a person's survival and determine if closer monitoring is needed in the years following surgery.
A recent study showed that women younger than 50 years who are pregnant or were recently pregnant at diagnosis of melanoma have a higher risk of death from the skin cancer.
Dabrafenib plus trametinib achieves good overall and progression-free survival in BRAF inhibitor-naïve patients with melanoma.
Using xenograft mice as avatars of patients with melanoma, scientists demonstrated that a previously ineffective targeted drug may halt disease progression in certain patients.
Circulating Tumor DNA More Effective Than LDH at Detecting Metastatic Melanoma Progression, Recurrence
Metastatic melanoma disease activity may be monitored via circulating tumor DNA, which has higher sensitivity than lactate dehydrogenase for detecting disease progression.
Twins carry a significant excess familial risk for cancer overall and for specific types of cancer, including prostate, melanoma, breast, ovary, and uterus, according to a long-term follow-up study of twins in Nordic countries.
A noninvasive technique designed to identify melanin pigment naturally found in melanoma tumor cells shows promise for detecting the spread of skin cancer.
A new compound, SBI-756, targets a specific molecular machine known as the translation initiation complex. These structures are in every cell and play the critical role of translating mRNA into proteins.
An international team of scientists has mapped out the genetic trajectories taken by melanoma as it evolves from early skin lesions to malignant skin cancer.
By introducing a particular strain of bacteria into the digestive tracts of mice with melanoma, researchers were able to boost the ability of the animal's immune systems to attack tumor cells. The gains were comparable to treatment with checkpoint inhibitors.
[OncoTargets and Therapy] This research examines the use of pembrolizumab for the management of advanced melanoma.
Metastasizing cells undergo metabolic changes, increasing their ability to withstand oxidative stress.
Talimogene laherparapvec (Imlygic) is the first FDA-approved oncolytic virus therapy.
Patients with melanoma who undergo surgical resection of abdominal metastases live more than twice as long as those treated with drug therapy alone, according to novel research presented at the American College of Surgeons Clinical Congress 2015.
Lesion-directed screening is comparably effective and may be less time consuming.
Antioxidants may double the rate of metastasis in malignant melanoma.
Current results from a clinical trial comparing a combination of two targeted therapies with a single-agent treatment for advanced melanoma has shown patients are living significantly longer with the combination therapy.
Skin self-examination (SSE) training to aid early detection of melanoma recurrence is beneficial for patients with melanoma and their partners, and has additional benefits for those who report having low relationship quality because it gives them activities to do together.
Online targeted advertising based on Google search terms may be an effective way to deliver targeted skin cancer prevention education.
Accelerated approval for nivolumab and ipilimumab for the treatment of patients with BRAF V600 wild-type unresectable or metastatic melanoma.
[OncoTargets and Therapy] This review focuses on the functional and molecular characteristics of programmed death receptor-1 (PD-1) and the clinical efficacy and tolerability of its antibody, nivolumab.
Neutrophil/lymphocyte ratio (NLR) before initiating ipilimumab is an independent prognostic indicator of poor survival.
[OncoTargets and Therapy] This research examines the current data on the efficacy and safety of trametinib in patients with metastaticBRAF V600-positive melanoma.
Organ transplant recipients are twice as likely to develop melanoma as people who do not undergo a transplant, and are three times more likely to die of the dangerous skin cancer, new research suggests.
Foot melanoma seems to represent a specific subgroup and is a negative independent prognostic factor for disease-specific survival, according to a study.
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- Incidence of Post-traumatic Stress Disorder High Among Patients With Cancer
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- Dietary Estrogens Reduced Efficacy of Novel Breast Cancer Therapy
- FDA Grants Breakthrough Therapy Designation to Lenvatinib Plus Pembrolizumab for RCC
- Bacteria in Probiotics Carry Potential Risks for Immunocompromised Patients
- Pertuzumab Regimen Approved for Adjuvant, Neoadjuvant Therapy in Specific Breast Cancers
- Artificial Sweeteners and Cancer Risk (Fact Sheet)
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- Breast Implants Associated With Increased Risk of Breast Anaplastic Large-cell Lymphoma
- Identifying the Psychosocial Needs of Young Adults With Metastatic Cancer
- BRCA Mutation Improves Prognosis for 2-year Survival in Younger-onset TNBC
- Patient Satisfaction Ratings Can Be Negatively Impacted by Nurse Staffing Ratio
- Dietary Estrogens Reduced Efficacy of Novel Breast Cancer Therapy
- Comparison of Survival Outcomes Between Radical Hysterectomy and Definitive Radiochemotherapy in Stage IB1 and IIA1 Cervical Cancer
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