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MEBARAL
Anxiety/OCD
Seizure disorders
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Drug Name:

MEBARAL CIV

Generic Name and Formulations:
Mephobarbital 32mg+ (½ grain), 50mg (¾ grain), 100mg (1½ grain); tabs; +scored.

Company:
Lundbeck Inc.

Therapeutic Use:

Indications for MEBARAL:

For use as a sedative for relief of anxiety, tension, and apprehension.

Adult:

50mg 3–4 times daily.

Children:

16–32mg 3–4 times daily.

Contraindications:

Manifest or latent porphyria.

Warnings/Precautions:

Premonitory signs of hepatic coma: not recommended. Impaired hepatic, renal, cardiac, respiratory function. Myasthenia gravis. Myxedema. Vit. D deficiency. Acute or chronic pain. Depression. Suicidal tendencies. Drug or alcohol abuse. Monitor hematopoietic, renal, hepatic systems with long-term therapy. Avoid abrupt cessation. Write ℞ for smallest practical amount. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat. D); may cause fetal damage. Nursing mothers.

Interactions:

Avoid concomitant griseofulvin. May antagonize oral anticoagulants (eg, warfarin), corticosteroids (may require dosage adjustments), doxycycline (monitor), oral contraceptives (consider alternative contraceptive method). May be potentiated by sodium valproate, valproic acid, MAOIs. Additive CNS depressant effects with alcohol, other CNS depressants. Concomitant phenytoin: monitor blood levels frequently.

Pharmacological Class:

Barbiturate.

Adverse Reactions:

Somnolence, agitation, confusion, hyperkinesia, ataxia, CNS depression, nightmares, nervousness, psychiatric disturbance, hallucination, insomnia, anxiety, dizziness, abnormal thinking, hypoventilation, apnea, bradycardia, hypotension, syncope, GI upset, constipation, headache, hypersensitivity reactions, fever, liver damage, megaloblastic anemia (chronic use).

How Supplied:

Tabs—250

Indications for MEBARAL:

For the treatment of grand mal and petit mal epilepsy.

Adult:

Initiate with small dose and increase gradually over 4 or 5 days. Usual range: 400mg–600mg daily. Concomitant phenobarbital: dose should be ½ the amount of each used alone. Concomitant phenytoin: reduce dose of phenytoin but give full dose of mephobarbital. Renal or hepatic impairment, elderly, debilitated: reduce dose.

Children:

<5yrs: 16–32mg 3 or 4 times daily. ≥5yrs: 32–64mg 3 or 4 times daily.

Contraindications:

Manifest or latent porphyria.

Warnings/Precautions:

Premonitory signs of hepatic coma: not recommended. Impaired hepatic, renal, cardiac, respiratory function. Myasthenia gravis. Myxedema. Vit. D deficiency. Acute or chronic pain. Depression. Suicidal tendencies. Drug or alcohol abuse. Monitor hematopoietic, renal, hepatic systems with long-term therapy. Avoid abrupt cessation. Write ℞ for smallest practical amount. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat. D); may cause fetal damage. Nursing mothers.

Interactions:

Avoid concomitant griseofulvin. May antagonize oral anticoagulants (eg, warfarin), corticosteroids (may require dosage adjustments), doxycycline (monitor), oral contraceptives (consider alternative contraceptive method). May be potentiated by sodium valproate, valproic acid, MAOIs. Additive CNS depressant effects with alcohol, other CNS depressants. Concomitant phenytoin: monitor blood levels frequently.

Pharmacological Class:

Barbiturate.

Adverse Reactions:

Somnolence, agitation, confusion, hyperkinesia, ataxia, CNS depression, nightmares, nervousness, psychiatric disturbance, hallucination, insomnia, anxiety, dizziness, abnormal thinking, hypoventilation, apnea, bradycardia, hypotension, syncope, GI upset, constipation, headache, hypersensitivity reactions, fever, liver damage, megaloblastic anemia (chronic use).

How Supplied:

Tabs—250

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