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MAXZIDE-25mg
Edema
Hypertension
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Drug Name:

MAXZIDE-25mg Rx

Generic Name and Formulations:
Triamterene 37.5mg, hydrochlorothiazide 25mg; scored tabs.

Company:
Mylan Inc.

Therapeutic Use:

Indications for MAXZIDE-25mg:

Edema.

Adult:

Initially one Maxzide-25mg tab/day. Usual dosage: 1–2 Maxzide-25mg tabs or one Maxzide tab once daily. As a substitute for triamterene 50–100mg/day and hydrochlorothiazide 25–50mg/day in less bioavailable form, give one Maxzide-25mg tab/day.

Children:

Not recommended.

Contraindications:

Hyperkalemia. Renal impairment. Anuria. Sulfonamide allergy. Concomitant potassium or K+-sparing diuretics.

Warnings/Precautions:

Diabetes. Acidosis predisposition. Electrolyte imbalance. Excessive diuresis. History of renal stones. Gout. Asthma. SLE. Surgery. Monitor electrolytes, renal function. Discontinue if serum potassium >5.5mEq/L or <3mEq/L. Hepatic impairment: monitor for hepatic coma, if confusion increases, discontinue for a few days. Elderly. Severely ill. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Hyperkalemia more likely with ACE inhibitors. NSAIDs may cause renal failure. Hypokalemia with corticosteroids, ACTH, amphotericin B. Hypotension with CNS depressants. Potentiates other antihypertensives, nondepolarizing muscle relaxants. Antagonized by NSAIDs. Hyponatremia with sulfonylureas. Antagonizes folic acid. May block epinephrine. May interfere with parathyroid tests.

See Also:

MAXZIDE

Pharmacological Class:

Diuretic (K+ sparing) + (thiazide).

Adverse Reactions:

Drowsiness, insomnia, muscle cramps, weakness, headache, GI disturbances, dizziness, orthostatic hypotension, hyperuricemia, impotence, renal stones, tachycardia, dyspnea, dry mouth, depression, anxiety, urine discoloration, elevated liver enzymes.

How Supplied:

Tabs—100, 500

Indications for MAXZIDE-25mg:

Hypertension when normokalemia is essential.

Adult:

1–2 tabs daily.

Children:

Not recommended.

Contraindications:

Hyperkalemia. Renal impairment. Anuria. Sulfonamide allergy. Concomitant potassium or K+-sparing diuretics.

Warnings/Precautions:

Diabetes. Acidosis predisposition. Electrolyte imbalance. Excessive diuresis. History of renal stones. Gout. Asthma. SLE. Surgery. Monitor electrolytes, renal function. Discontinue if serum potassium >5.5mEq/L or <3mEq/L. Hepatic impairment: monitor for hepatic coma, if confusion increases, discontinue for a few days. Elderly. Severely ill. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Hyperkalemia more likely with ACE inhibitors. NSAIDs may cause renal failure. Hypokalemia with corticosteroids, ACTH, amphotericin B. Hypotension with CNS depressants. Potentiates other antihypertensives, nondepolarizing muscle relaxants. Antagonized by NSAIDs. Hyponatremia with sulfonylureas. Antagonizes folic acid. May block epinephrine. May interfere with parathyroid tests.

See Also:

MAXZIDE

Pharmacological Class:

Diuretic (K+ sparing) + (thiazide).

Adverse Reactions:

Drowsiness, insomnia, muscle cramps, weakness, headache, GI disturbances, dizziness, orthostatic hypotension, hyperuricemia, impotence, renal stones, tachycardia, dyspnea, dry mouth, depression, anxiety, urine discoloration, elevated liver enzymes.

How Supplied:

Tabs—100, 500

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