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Melanoma tumors create conditions that attract immunoglobulin G4 (IgG4), the B-cell antibody class least effective in activating immune response.
Inhibiting one protein eliminated metastasis of melanoma in lab studies, a finding that could lead to targeted therapies for a range of cancers.
Excessive levels of interleukin-15 initiate large granular lymphocyte (LGL) leukemia, but also represent a promising therapeutic target.
For ovarian cancer and perhaps other cancer types, cell stiffness may be a useful biomarker to measure relative metastatic potential.
Assessing how water moves through breast tissue may reduce false-positive findings among women undergoing dynamic contrast-enhanced MRI.
The quality of breast cancer surgery improved when percutaneous needle biopsy was performed preoperatively.
Two drugs under FDA evaluation slowed treatment resistance in persons with metastatic malignant melanoma positive for the BRAF protein.
An analysis of breath samples from patients with pulmonary nodules distinguished benign from malignant growths in a recent study.
A controlled fasting period lasting no more than 48 hours improved the effectiveness of chemotherapy and radiation therapy in mice with gliomas.
Persons with more than one glioblastoma tumor upon diagnosis experience significantly worse survival than do patients with a solitary lesion.
A slower-growing set of glioblastoma multiforme cells appears to be the source of the brain cancer's recurrence following standard drug therapy.
Most of the hundreds of mutations found in acute myeloid leukemia (AML) genomes occur randomly as part of the aging process, unrelated to cancer.
August 15, 2012
Research results suggest that of the billions of cancer cells that exist in a patient, only about one in a million is resistant to drugs using targeted therapy.
Scientists have identified a protein that makes some children and teenagers afflicted with Ewing sarcoma more resistant to chemotherapy.
In patients with a previous head and neck cancer, liposuction is a well-tolerated surgical treatment for persistent submental lymphedema.
Dabrafenib, which targets a genetic mutation that is active in half of melanoma cases, substantially and safely shrank metastatic tumors.
Drug Safety Communication on lenalidomide (Revlimid); FDA approval for pazopanib (Votrient)
The Breast Imaging Reporting and Data System (BI-RADS) terminology is useful in predicting malignancy in breast lesions detected with MRI.
A specific genomic abnormality found in either benign or malignant prostate tissues is predictive of the clinical outcome of prostate cancer.
The system for monitoring adverse events in oncology clinical trials is in urgent need of reform, say the authors of a recent commentary.
The current trend is to preserve pregnancy in women diagnosed with cervical or ovarian cancer whenever feasible, according to a recent review.
Sorafenib, sunitinib, and pazopanib have been found to carry a heightened risk of fatal complications, but the incidence remains low overall.
Genetic evaluations by a multidisciplinary health team improved risk prediction for children with retinoblastoma and their relatives, and prevented overuse of clinical screening tests.
A regimen using minimal-intensity radiation therapy before bone marrow or stem cell transplantation may work for older patients who cannot tolerate stronger pretransplant treatment.
Compared with the general population, recipients of a kidney, liver, heart, or lung transplant have twice as great a risk for diverse infection-related and unrelated cancers.
An emerging application known as magnetic relaxometry demonstrated 100 times greater sensitivity than mammography imaging in identifying breast tumors.
The often difficult task of detecting whether advanced squamous cell carcinoma in the oral cavity has invaded the mandible may be made easier with an MRI technique known as SWIFT.
A surgical method employing fluorescent imaging agents can help surgeons remove malignant tissue that otherwise might have been missed in women with ovarian cancer.
Lunasin, a soy peptide, keeps highly metastatic colon cancer cells from spreading by binding to a specific receptor, according to recent research findings.
The regulatory protein FoxM1 is essential for the continued growth of medulloblastoma and is significantly and negatively correlated with survival, making it a useful prognostic marker.
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