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Magnesium Sulfate Injection
Vitamins, minerals, supplements
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Drug Name:

Magnesium Sulfate Injection Rx

Generic Name and Formulations:
Magnesium sulfate 500mg/mL; soln for IM inj; or IV use after dilution; contains aluminum.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Magnesium Sulfate Injection:

Magnesium deficiency.

Adult:

Mild deficiency: 1g IM every 6 hours for four doses. Severe deficiency: 250mg/kg IM within a period of 4 hours if necessary; alternatively 5g may be added to one liter of 5% dextrose inj or 0.9% sodium chloride inj for slow IV infusion over a 3-hour period. TPN: usual range: 1–3g (8–24mEq) daily. Severe renal impairment: max 20g in 48 hours.

Children:

TPN for infants: usual range: 0.25–1.25g (2–10mEq) daily.

Contraindications:

Heart block. Myocardial damage.

Warnings/Precautions:

Renal impairment. Monitor serum magnesium levels; if repeated doses are given, test knee jerk reflexes before each dose. Have injectable calcium salt readily available to counteract magnesium intoxication. Elderly. Premature neonates. Pregnancy (Cat.D). Nursing mothers.

Interactions:

Additive CNS depressant effects with barbiturates, narcotics, other hypnotics; adjust dose. Potentiates neuromuscular blocking agents. Concomitant cardiac glycosides; use extreme caution, heart block may occur.

Adverse Reactions:

Magnesium intoxication (eg, flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and CNS depression proceeding to respiratory paralysis.

Note:

Formerly known under the brand name Sulfamag.

How Supplied:

Contact supplier.

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