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LYRICA
Fibromyalgia
Nonnarcotic analgesics
Seizure disorders
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Drug Name:

LYRICA CV

Generic Name and Formulations:
Pregabalin 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg; caps.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for LYRICA:

Fibromyalgia.

Adult:

≥18yrs: initially 75mg twice daily, may increase to 150mg twice daily within 1 week as tolerated; max 450mg/day. Renal impairment (CrCl <60mL/min): reduce dose (see literature); hemodialysis: give supplemental dose after session.

Children:

<18yrs: not recommended.

Warnings/Precautions:

Avoid abrupt cessation (taper over ≥1 week). Discontinue if angioedema, hypersensitivity reactions, myopathy or markedly elevated creatine kinase levels occur. CHF. Ocular conditions. Diabetes (monitor skin integrity). Suicidal tendencies (monitor). Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Additive edema, weight gain with thiazolidinediones.

See Also:

LYRICA ORAL SOLUTION

Pharmacological Class:

Alpha-2 delta ligand.

Adverse Reactions:

Dizziness, somnolence, other CNS effects, dry mouth, edema, ocular/visual effects (eg, blurring), weight gain, thinking abnormal (primarily difficulty with concentration/attention), infection, asthenia, paresthesias, elevated creatine kinase, decreased platelets, arrhythmias (PR prolongation); male-mediated teratogenicity; may be tumorigenic.

How Supplied:

Caps—90; Soln—16oz

Indications for LYRICA:

Neuropathic pain associated with diabetic peripheral neuropathy (DPN) or spinal cord injury. Postherpetic neuralgia (PHN).

Adult:

≥18yrs: DPN: initially 50mg 3 times daily, may increase to 100mg 3 times daily within 1 week. Spinal cord injury: initially 75mg twice daily, may increase to 150mg twice daily within 1 week, then max 600mg/day after 2 weeks as tolerated. PHN: initially 75mg twice daily or 50mg 3 times daily; max 300mg/day after 1 week then 600mg/day after 2 weeks as tolerated (see literature). For all: renal impairment (CrCl <60mL/min): reduce dose (see literature); hemodialysis: give supplemental dose after session.

Children:

<18yrs: not recommended.

Warnings/Precautions:

Avoid abrupt cessation (taper over ≥1 week). Discontinue if angioedema, hypersensitivity reactions, myopathy or markedly elevated creatine kinase levels occur. CHF. Ocular conditions. Diabetes (monitor skin integrity). Suicidal tendencies (monitor). Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Additive edema, weight gain with thiazolidinediones.

See Also:

LYRICA ORAL SOLUTION

Pharmacological Class:

Alpha-2 delta ligand.

Adverse Reactions:

Dizziness, somnolence, other CNS effects, dry mouth, edema, ocular/visual effects (eg, blurring), weight gain, thinking abnormal (primarily difficulty with concentration/attention), infection, asthenia, paresthesias, elevated creatine kinase, decreased platelets, arrhythmias (PR prolongation); male-mediated teratogenicity; may be tumorigenic.

How Supplied:

Caps—90; Soln—16oz

Indications for LYRICA:

Adjunct in partial onset seizures.

Adult:

≥18yrs: Give in 2–3 divided doses. Initially 150mg/day, max 600mg/day. Renal impairment (CrCl <60mL/min): reduce dose (see literature); hemodialysis: give supplemental dose after session.

Children:

<18yrs: not recommended.

Warnings/Precautions:

Avoid abrupt cessation (taper over ≥1 week). Discontinue if angioedema, hypersensitivity reactions, myopathy or markedly elevated creatine kinase levels occur. CHF. Ocular conditions. Diabetes (monitor skin integrity). Suicidal tendencies (monitor). Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Additive edema, weight gain with thiazolidinediones.

See Also:

LYRICA ORAL SOLUTION

Pharmacological Class:

Alpha-2 delta ligand.

Adverse Reactions:

Dizziness, somnolence, other CNS effects, dry mouth, edema, ocular/visual effects (eg, blurring), weight gain, thinking abnormal (primarily difficulty with concentration/attention), infection, asthenia, paresthesias, elevated creatine kinase, decreased platelets, arrhythmias (PR prolongation); male-mediated teratogenicity; may be tumorigenic.

How Supplied:

Caps—90; Soln—16oz

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