Lung Cancer

Smoking Cessation at Any Age Beneficial

Smoking Cessation at Any Age Beneficial

Even patients that quit smoking in their 60s can add years to their lives, researchers find.

Mental Health Disorder Linked to Poorer Survival in NSCLC

Mental Health Disorder Linked to Poorer Survival in NSCLC

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Among patients with non-small cell lung cancer (NSCLC), those with a mental health disorder appeared to have a higher risk of death.

Intermittent Hypoxia Promotes Lung Tumor Cell Aggressiveness

Intermittent Hypoxia Promotes Lung Tumor Cell Aggressiveness

IH-induced exosomes from mice significantly promote TC1 malignant properties, according to a recent study.

CDC: Tobacco-Linked Cancers Still Make Up 40 Percent of All Cancers

CDC: Tobacco-Linked Cancers Still Make Up 40 Percent of All Cancers

Fewer people smoking, but cancer burden still high in the U.S.

Vandetanib Potentially Efficacious in RET-Rearranged NSCLC

Vandetanib Potentially Efficacious in RET-Rearranged NSCLC

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In a multicenter, open-label, phase 2 study, researchers evaluated the activity and safety of vandetanib in patients with advanced RET-rearranged NSCLC.

Vandetanib Moderately Active in RET+ Advanced NSCLC

Vandetanib Moderately Active in RET+ Advanced NSCLC

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Researchers report on their evaluation of the efficacy and safety of vandetanib, a kinase inhibitor of VEGFR, EGFR, and the RET-tyrosine kinase, in patients with NSCLC tumors with chromosomal rearrangements involving RET.

HIIT Improves Cardiorespiratory Fitness in Patients With Resectable NSCLC

HIIT Improves Cardiorespiratory Fitness in Patients With Resectable NSCLC

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This study focused on determining the effectiveness of a short-term high-intensity interval training (HIIT) program to improve patients' cardiorespiratory fitness prior to NSCLC resection.

Smoking-related Cancer Deaths Highest in Southern United States

Smoking-related Cancer Deaths Highest in Southern United States

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Smoking-attributable cancer mortality estimates have not been established by state; therefore, in this study, the proportion of cancer deaths among persons 35 years and older related to cigarette smoking in 2014 was calculated for each state and DC.

Atezolizumab Granted FDA Approval for Specific Cases of NSCLC

Atezolizumab Granted FDA Approval for Specific Cases of NSCLC

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Atezolizumab (Tecentriq) is approved by the FDA for the treatment of metastatic NSCLC in specific cases or tumors with EGFR or ALK gene mutations.

First-line Pembrolizumab + Chemo Could Be Effective for Non-squamous NSCLC

First-line Pembrolizumab + Chemo Could Be Effective for Non-squamous NSCLC

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The addition of pembrolizumab to carboplatin and pemetrexed improves overall response rate compared with chemotherapy alone and has a manageable safety profile in patients with newly diagnosed advanced nonsquamous NSCLC.

Lenvatinib Shows Promising Activity in RET+ NSCLC

Lenvatinib Shows Promising Activity in RET+ NSCLC

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Treatment with the kinase inhibitor lenvatinib demonstrated promising activity in patients with RET-positive NSCLC.

Depression Linked to Increased Mortality in Lung Cancer

Depression Linked to Increased Mortality in Lung Cancer

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Changes in depression symptoms over time are associated with differences in survival among patients with lung cancer, especially those with early stage disease.

Decision Aids Help Patients Understand Lung Cancer Screening

Decision Aids Help Patients Understand Lung Cancer Screening

Patient understanding of lung cancer screening increased after participation in focus groups.

Study Supports Routine Use of IMRT for Locally Advanced NSCLC

Study Supports Routine Use of IMRT for Locally Advanced NSCLC

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IMRT was associated with lower rates of severe pneumonitis and cardiac doses compared with 3D-CRT in patients with locally advanced NSCLC.

Analysis of Population Trends Shows Use of Electronic Cigarettes Increase Quit Success

Analysis of Population Trends Shows Use of Electronic Cigarettes Increase Quit Success

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An analysis of population trends in England demonstrated that use of electronic cigarettes improves the rate of successful quit attempts, but results in less use of prescription nicotine-replacement therapy products.

WBRT Adds Little Benefit for NSCLC With Brain Metastases

WBRT Adds Little Benefit for NSCLC With Brain Metastases

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Adding WBRT to dexamethasone and best supportive care provides little additional benefit for patients with NSCLC and brain metastases who are ineligible to undergo resection or stereotactic radiotherapy.

Adding Vandetanib to Platinum + Etoposide Not Effective for SCLC

Adding Vandetanib to Platinum + Etoposide Not Effective for SCLC

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The addition of vandetanib to a platinum agent and etoposide did not improve time to progression or overall survival in patients with newly diagnosed extensive-stage SCLC.

Combination Therapy With Hypoxia-Activated Prodrug Prevents Drug Resistance in NSCLC Subtype

Combination Therapy With Hypoxia-Activated Prodrug Prevents Drug Resistance in NSCLC Subtype

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Hypoxia-activated prodrugs prevented treatment resistance in a mathematical model of EGFR mutation-driven non-small cell lung cancer (NSCLC).

Clinician Answers on Safety of E-Cigarettes Vary

Clinician Answers on Safety of E-Cigarettes Vary

When patients ask about safety and using e-cigarettes to stop smoking, doctors give varying advice.

TKIs Improve Overall Survival in NSCLC Patients With Leptomeningeal Metastases

TKIs Improve Overall Survival in NSCLC Patients With Leptomeningeal Metastases

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Longer overall survival was achieved with TKIs targeting EGFR mutations in non-small cell lung cancer (NSCLC) patients.

Study Evaluates Incidence of PD-1 Blockade-related Pneumonitis

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Pneumonitis related to the use of PD-1 inhibitor therapy is higher among patients with NSCLC and RCC, and during combination therapy.

In NSCLC, Erlotinib Appears Effective at Doses Lower Than MTD

In NSCLC, Erlotinib Appears Effective at Doses Lower Than MTD

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Patients with metastatic non-small cell lung cancer demonstrated prolonged median progression-free survival with the administration of erlotinib below the maximum tolerated dose.

Hybrid Immune Cells Have Antitumor Effects in Early Stage Lung Cancer

Hybrid Immune Cells Have Antitumor Effects in Early Stage Lung Cancer

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A subset of tumor-associated neutrophils (TANs) has hybrid characteristics of both neutrophils and antigen-presenting cells in samples from early stage human lung cancers.

Web Application Improves Follow-up in Patients With Advanced Lung Cancer

Web Application Improves Follow-up in Patients With Advanced Lung Cancer

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A Web application called Moovcare that guides follow-up improved survival for patients with advanced lung cancer after receiving initial therapy.

A Systematic Review and Meta-analysis of the Risk of Diarrhea Associated With Vandetanib Treatment in Carcinoma Patients

A Systematic Review and Meta-analysis of the Risk of Diarrhea Associated With Vandetanib Treatment in Carcinoma Patients

[OncoTargets and Therapy] This research examines overall risks of all-grade and high-grade diarrhea during vandetanib treatment, to gain a better understanding of its prediction and management.

Annual Follow-up With Low-Dose CT Is Sufficient for Some Lung Nodules

Annual Follow-up With Low-Dose CT Is Sufficient for Some Lung Nodules

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For nonsolid nodules identified by CT screening for lung cancer, annual screening with low-dose CT can eliminate the need for biopsy or surgery.

Nonsolid Nodules Unlikely to Cause Death in Lung Cancer

Nonsolid Nodules Unlikely to Cause Death in Lung Cancer

Lung cancers that manifest as nonsolid nodules seem to have indolent course, according to recent research data.

Electronic Cigarettes May Cause Damage to Oral Epithelial Cells

Electronic Cigarettes May Cause Damage to Oral Epithelial Cells

Findings suggest a possible increase in the risk of oral disease caused by e-cigarette use.

Surgery Improves Quality of Life for Patients With Malignant Pleural Mesothelioma

Surgery Improves Quality of Life for Patients With Malignant Pleural Mesothelioma

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Undergoing pleurectomy and decortication for malignant pleural mesothelioma generally leads to improved quality of life after the surgery.

Lung Cancer Signature Detected Via Breath Test Improves Early Diagnosis

Lung Cancer Signature Detected Via Breath Test Improves Early Diagnosis

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Breath analysis offers an option for both primary screening and postsurgery monitoring of patients with lung cancer. Exhaled breath has certain carbonyl VOCs that indicate the presence of lung cancer in a process researchers hope will receive FDA approval.

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