Lung Cancer

No Differences in Lung Cancer Mutations Between White, Black Patients

No Differences in Lung Cancer Mutations Between White, Black Patients

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Analyses of lung tumor specimens were used to determine whether mutational profiles of lung cancers differ between black and white patients. Such differences could explain differences in prognosis and lead to reductions in outcomes disparities.

Lung Cancer Navigator App Aims to Help Patients Understand Disease

Lung Cancer Navigator App Aims to Help Patients Understand Disease

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Lung Cancer Navigator, a mobile, customizable app from LUNGEVITY, helps patients with lung cancer better understand their disease, manage medications, track symptoms, and access support.

Considerable Shifts in NSCLC Treatment With Modest Gains in Survival

Considerable Shifts in NSCLC Treatment With Modest Gains in Survival

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Investigators report on trends in treatment of advanced-stage NSCLC from 2000 to 2011, including impact on survival and total Medicare spending.

Delayed Adjuvant Chemotherapy Not Associated With Survival in NSCLC

Delayed Adjuvant Chemotherapy Not Associated With Survival in NSCLC

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Study evaluated differences in survival with respect to the time interval between tumor resection and initiation of postoperative chemotherapy in patients with NSCLC.

Comparison of Three Information Sources for Smoking Information in Electronic Health Records

Comparison of Three Information Sources for Smoking Information in Electronic Health Records

[Cancer Informatics] This research examinbed independent and joint performance of retrieving smoking status through different sources and compared the performance of retrieving smoking strength information from narrative text and PPI.

Stepped Psychological Care for Patients with Head and Neck or Lung Cancer

Stepped Psychological Care for Patients with Head and Neck or Lung Cancer

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For patients with head and neck or lung cancer, stepped care programs may offer a more affordable yet effective approach.

The evolution of the diminishing role of extrapleural pneumonectomy in the surgical management of malignant pleural mesothelioma

The evolution of the diminishing role of extrapleural pneumonectomy in the surgical management of malignant pleural mesothelioma

[OncoTargets and Therapy] The surgical approach that offers the best outcomes for malignant pleural mesothelioma management is still debated. This research examines the efficacy of surgical treatment.

Cisplatin-etoposide and Carboplatin-paclitaxel With RT Comparable for Stage III Lung Cancer

Cisplatin-etoposide and Carboplatin-paclitaxel With RT Comparable for Stage III Lung Cancer

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Carboplatin-paclitaxel with concurrent RT has comparable efficacy with cisplatin-etoposide plus RT in patients with stage III NSCLC.

Atezolizumab Prolongs Survival vs Docetaxel in Previously Treated NSCLC

Atezolizumab Prolongs Survival vs Docetaxel in Previously Treated NSCLC

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The efficacy and safety of atezolizumab in patients with previously treated NSCLC was evaluated in the OAK trial, an open-label, pivotal, phase 3 study, the results of which were recently published.

Survival Not Better With Onartuzumab Plus Erlotinib for MET-Positive NSCLC

Survival Not Better With Onartuzumab Plus Erlotinib for MET-Positive NSCLC

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Results of the METLung trial are presented. In this trial, researchers evaluated the efficacy and safety of onartuzumab in patients with advanced NSCLC selected by MET immunohistochemistry.

Osimertinib New Standard of Care for T790M+ Advanced NSCLC

Osimertinib New Standard of Care for T790M+ Advanced NSCLC

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A study presented at the World Conference on Lung Cancer compared progression-free survival after treatment with osimertinib with that of platinum therapy plus pemetrexed in a select group of patients with T790M-positive advanced NSCLC.

Smoking Cessation at Any Age Beneficial

Smoking Cessation at Any Age Beneficial

Even patients that quit smoking in their 60s can add years to their lives, researchers find.

Mental Health Disorder Linked to Poorer Survival in NSCLC

Mental Health Disorder Linked to Poorer Survival in NSCLC

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Among patients with non-small cell lung cancer (NSCLC), those with a mental health disorder appeared to have a higher risk of death.

Intermittent Hypoxia Promotes Lung Tumor Cell Aggressiveness

Intermittent Hypoxia Promotes Lung Tumor Cell Aggressiveness

IH-induced exosomes from mice significantly promote TC1 malignant properties, according to a recent study.

CDC: Tobacco-Linked Cancers Still Make Up 40 Percent of All Cancers

CDC: Tobacco-Linked Cancers Still Make Up 40 Percent of All Cancers

Fewer people smoking, but cancer burden still high in the U.S.

Vandetanib Potentially Efficacious in RET-Rearranged NSCLC

Vandetanib Potentially Efficacious in RET-Rearranged NSCLC

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In a multicenter, open-label, phase 2 study, researchers evaluated the activity and safety of vandetanib in patients with advanced RET-rearranged NSCLC.

Vandetanib Moderately Active in RET+ Advanced NSCLC

Vandetanib Moderately Active in RET+ Advanced NSCLC

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Researchers report on their evaluation of the efficacy and safety of vandetanib, a kinase inhibitor of VEGFR, EGFR, and the RET-tyrosine kinase, in patients with NSCLC tumors with chromosomal rearrangements involving RET.

HIIT Improves Cardiorespiratory Fitness in Patients With Resectable NSCLC

HIIT Improves Cardiorespiratory Fitness in Patients With Resectable NSCLC

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This study focused on determining the effectiveness of a short-term high-intensity interval training (HIIT) program to improve patients' cardiorespiratory fitness prior to NSCLC resection.

Smoking-related Cancer Deaths Highest in Southern United States

Smoking-related Cancer Deaths Highest in Southern United States

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Smoking-attributable cancer mortality estimates have not been established by state; therefore, in this study, the proportion of cancer deaths among persons 35 years and older related to cigarette smoking in 2014 was calculated for each state and DC.

Atezolizumab Granted FDA Approval for Specific Cases of NSCLC

Atezolizumab Granted FDA Approval for Specific Cases of NSCLC

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Atezolizumab (Tecentriq) is approved by the FDA for the treatment of metastatic NSCLC in specific cases or tumors with EGFR or ALK gene mutations.

First-line Pembrolizumab + Chemo Could Be Effective for Non-squamous NSCLC

First-line Pembrolizumab + Chemo Could Be Effective for Non-squamous NSCLC

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The addition of pembrolizumab to carboplatin and pemetrexed improves overall response rate compared with chemotherapy alone and has a manageable safety profile in patients with newly diagnosed advanced nonsquamous NSCLC.

Lenvatinib Shows Promising Activity in RET+ NSCLC

Lenvatinib Shows Promising Activity in RET+ NSCLC

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Treatment with the kinase inhibitor lenvatinib demonstrated promising activity in patients with RET-positive NSCLC.

Depression Linked to Increased Mortality in Lung Cancer

Depression Linked to Increased Mortality in Lung Cancer

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Changes in depression symptoms over time are associated with differences in survival among patients with lung cancer, especially those with early stage disease.

Decision Aids Help Patients Understand Lung Cancer Screening

Decision Aids Help Patients Understand Lung Cancer Screening

Patient understanding of lung cancer screening increased after participation in focus groups.

Study Supports Routine Use of IMRT for Locally Advanced NSCLC

Study Supports Routine Use of IMRT for Locally Advanced NSCLC

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IMRT was associated with lower rates of severe pneumonitis and cardiac doses compared with 3D-CRT in patients with locally advanced NSCLC.

Analysis of Population Trends Shows Use of Electronic Cigarettes Increase Quit Success

Analysis of Population Trends Shows Use of Electronic Cigarettes Increase Quit Success

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An analysis of population trends in England demonstrated that use of electronic cigarettes improves the rate of successful quit attempts, but results in less use of prescription nicotine-replacement therapy products.

WBRT Adds Little Benefit for NSCLC With Brain Metastases

WBRT Adds Little Benefit for NSCLC With Brain Metastases

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Adding WBRT to dexamethasone and best supportive care provides little additional benefit for patients with NSCLC and brain metastases who are ineligible to undergo resection or stereotactic radiotherapy.

Adding Vandetanib to Platinum + Etoposide Not Effective for SCLC

Adding Vandetanib to Platinum + Etoposide Not Effective for SCLC

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The addition of vandetanib to a platinum agent and etoposide did not improve time to progression or overall survival in patients with newly diagnosed extensive-stage SCLC.

Combination Therapy With Hypoxia-Activated Prodrug Prevents Drug Resistance in NSCLC Subtype

Combination Therapy With Hypoxia-Activated Prodrug Prevents Drug Resistance in NSCLC Subtype

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Hypoxia-activated prodrugs prevented treatment resistance in a mathematical model of EGFR mutation-driven non-small cell lung cancer (NSCLC).

Clinician Answers on Safety of E-Cigarettes Vary

Clinician Answers on Safety of E-Cigarettes Vary

When patients ask about safety and using e-cigarettes to stop smoking, doctors give varying advice.

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