For patients with small cell lung cancer, chest radiotherapy increases survival, decreases recurrence
the ONA take:
According to a new study published in The Lancet, patients with advanced small cell lung cancer (SCLC) experienced prolonged survival and reduced recurrence of the disease after being treated prophylactic cranial radiotherapy plus thoracic radiotherapy compared with those treated with prophylactic cranial radiotherapy alone.
In the phase 3 clinical study, researchers enrolled 498 adults with advanced SCLC who had already responded to first-line chemotherapy from 42 hospitals in Europe. Patients were randomized to receive either prophylactic cranial radiotherapy plus chest radiotherapy or prophylactic cranial radiotherapy alone. Radiation was administered over 2 weeks and patients were followed for an average of 2 years.
The researchers found that patients survival rates were similar between both groups after 1 year, but they found that after 2 years, 13% of patients treated with combination radiotherapy were alive, while only 3% of those treated with prophylactic cranial radiotherapy were alive. In addition, 20% those who received combination radiotherapy experienced recurrence in the thoracic region compared with 46% of the cranial radiotherapy group.
The authors suggest that chest radiation therapy should be considered as a treatment approach in patients with extensive small cell lung cancer who have responded to first-line chemotherapy.
SCLC patients experienced prolonged survivalafter being treated prophylactic cranial radiotherapy.
For patients with advanced small cell lung cancer, thoracic radiotherapy alongside standard treatment may boost long-term survival and reduce the likelihood of cancer recurrence in the chest, according to researchers.
Small cell lung cancer (SCLC) accounts for around 10-15% of all lung cancer cases. It is almost always caused by smoking and tends to spread rapidly to other parts of the body, meaning it is often diagnosed in its advanced stages.
- Clinical Trials May Benefit Oncology Patients
- Breast Cancer Overdiagnosis Also a Result of Screening Mammography Programs
- Prostate-specific PET and CT Imaging Improves Detection of Disease and Patient Care
- Cancer Risk Not Increased by Childhood Exposure to Diagnostic Radiation
- Aspirin Use May Lower Breast Cancer Risk in Women with Diabetes
- Survivorship Care Plans: Providing A Blueprint for Health Care After Cancer
- Multifaceted Role of the Nurse Navigator Includes Palliative, Supportive Care
- Cancer Recurrence Fear Reduced by Novel Psychological Intervention
- Patient Navigators Found to Boost Lung Cancer Screening Rates
- Immune Thrombocytopenia (Fact Sheet)
- Novel 3D Marker Reduces Radiation, Improves Cosmesis in Breast Conserving Surgery
- Rates at Some Milestones May Indicate Clinical Trial Results for Immunotherapeutics
- Cancer Risks for BRCA1/2 Mutation Carriers Determined by Age, Family History, Mutation Location
- Long-Term Use of TPO Receptor Agonist Safe in CLL-Associated Immune Thrombocytopenia
- Savolitinib Active, Tolerable in Subset of Advanced Papillary Renal Cell Cancer
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|