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LOFIBRA CAPSULES
Hyperlipoproteinemias
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Drug Name:

LOFIBRA CAPSULES Rx

Generic Name and Formulations:
Fenofibrate 67mg, 134mg, 200mg; caps (micronized).

Company:
Teva Pharmaceuticals

Therapeutic Use:

Indications for LOFIBRA CAPSULES:

Adjunct to diet in hypertriglyceridemia (Types IV and V), and to reduce elevated total-C, LDL-C, apo B, and TG, and to increase HDL-C, in primary hypercholesterolemia and mixed dyslipidemia (Types IIa and IIb).

Adult:

Take with food. Hypertriglyceridemia: 67–200mg/day; adjust in 4–8 week intervals; max 200mg/day. Hypercholesterolemia, dyslipidemia: 200mg/day. Renal impairment (CrCl<50mL/min): initially 67mg/day. Discontinue if inadequate response after 2 months on max dose.

Children:

Not recommended.

Elderly:

Initially 67mg/day.

Contraindications:

Hepatic dysfunction. Primary biliary cirrhosis. Severe renal dysfunction. Gallbladder disease.

Warnings/Precautions:

Renal impairment. Monitor CBCs for first year; monitor liver function, discontinue if ALT (SGPT) levels >3xULN persist. Discontinue if markedly elevated CPK levels, myopathy, or gallstones occur. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Avoid statins. Potentiates oral anticoagulants (monitor). Allow at least 1 hour before or 4–6 hours after bile acid sequestrants. Caution with immunosuppressants (eg, cyclosporine), other nephrotoxic drugs.

See Also:

LOFIBRA TABLETS

Pharmacological Class:

Fibrate.

Adverse Reactions:

Abnormal liver function tests, elevated CPK, respiratory or GI effects, myopathy, cholelithiasis, pancreatitis, increased creatinine, rash; rare: rhabdomyolysis, transient hematologic changes, blood dyscrasias.

How Supplied:

Tabs—90
Caps—100

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