Gene mutation may lead to treatment for liver cancer

Two genetic mutations in liver cells may drive tumor formation in intrahepatic cholangiocarcinoma (iCCA), the second most common form of liver cancer, according to new research.

Everolimus does not affect survival rate for advanced liver cancer

Everolimus does not affect survival rate for advanced liver cancer

No considerable survival difference found between patients receiving everolimus and those receiving a placebo.

Poor lifestyle choices blamed for large rise In liver and skin cancers

Poor lifestyle choices blamed for large rise In liver and skin cancers

Lifestyle factors such as overeating, smoking, drinking too much and not enough exercises may be to blame for a sharp rise in liver and skin cancer cases.

Hepatocellular carcinoma with no cirrhosis

Hepatocellular carcinoma with no cirrhosis

What is currently known about stage IV well-differentiated liver cancer with no cirrhosis?

HBV therapy may reduce liver cancer risk

HBV therapy may reduce liver cancer risk

Antiviral treatment for hepatitis B virus (HBV) may be associated with a lower risk of hepatocellular carcinoma, researchers reported.

Antiviral therapy may prevent liver cancer in patients with hepatitis B

Antiviral therapy may prevent liver cancer in patients with hepatitis B

Researchers have found that antiviral therapy may be successful in preventing hepatitis B virus from developing into the most common form of liver cancer, hepatocellular carcinoma (HCC).

Pancreatic cancer to become second-leading cause of cancer death by 2030

An analysis projects pancreatic and liver cancers will become second and third leading causes of cancer-related death in the United States by 2030, respectively, behind lung cancer, which will remain the number one killer.

Patient factors affect AFP detection of liver cancer

Patient factors affect AFP detection of liver cancer

Measurement of -fetoprotein detects hepatocellular carcinoma (HCC) most accurately in patients without hepatitis C virus (HCV) infection, according to a study.

3D MRI predicts survival after chemotherapy for liver tumors

3D MRI predicts survival after chemotherapy for liver tumors

In a series of studies involving Americans with liver tumors, researchers used specialized three-dimensional MRI scans to precisely measure whether highly toxic chemotherapy is working.

AACR: Coffee consumption may lower liver cancer risk

AACR: Coffee consumption may lower liver cancer risk

Increased coffee consumption may reduce hepatocellular carcinoma (HCC) risk across ethnicities, according to a study.

Oncogene driving liver cancer identified as UHRF1

By combining a zebrafish model of liver cancer with data from human tumors, researchers hope to identify potential genes of interest that can be targeted for new treatments for hepatocellular carcinoma.

Higher liver cancer rates in men explained by males-only HBV mutation

A team of researchers has identified a novel mutation in the hepatitis B virus (HBV) in Korea that appears only in men and could help explain why HBV-infected men are roughly five times more likely than HBV-infected women to develop liver cancer.

Liver cancer progenitor cells identified before tumors can be detected

Researchers have isolated and characterized the progenitor cells that give rise to malignant hepatocellular carcinoma tumors long before the actual tumors can be detected.

Coffee consumption may reduce liver cancer

Coffee consumption may reduce liver cancer

Meta-analysis pooled the results of 16 studies that examined the association between coffee consumption and liver cancer and coffee consumption was associated with a significantly lower risk of HCC.

Liver Cancer (Fact Sheet)

This fact sheet reviews primary and secondary liver cancer types, symptoms, screening, and treatment.

Treating hepatocellular carcinoma with transarterial chemoembolization and selective internal radiotherapy

New light was shed on the use of TACE and SIRT in the treatment of hepatocellular carcinoma (HCC) by data from clinical trials presented at the International Liver Congress 2013 in Amsterdam, the Netherlands.

Novel tests improve diagnosis of two types of liver cancer

New data from two clinical trials presented at the International Liver Congress 2013 demonstrated substantial improvements in the detection of both HCC and cholangiocarcinoma using diagnostic urine tests.

Cetuximab enables liver metastasis surgery in colorectal cancer

Combining cetuximab (Erbitux) with standard therapy improved the resectability of previously inoperable liver metastases of colorectal cancer.

Measuring hepatic function can be used to plan treatment for liver cancer patients

Monitoring the hepatic function of unresectable liver cancer patients provides vital information that could guide more customized treatment plans and reduce risks of liver injury.

Heart drugs turn cancer cells into anticancer vaccines

Plant-based drugs primarily used in the treatment of heart failure and arrhythmias have now been found to exert anticancer effects.

Vitamin E intake inversely linked to liver cancer risk

Vitamin E intake inversely linked to liver cancer risk

Vitamin E from diet or supplements may reduce the risk of developing liver cancer.

Weight and inactivity impact cancer rates

Weight and inactivity impact cancer rates

Overall US cancer death rates have continued to decline since the early 1990s, but excess weight and lack of sufficient activity contribute to the increased incidence of many cancers.

Thiazolidinediones tied to lower cancer risk in diabetes patients

Thiazolidinediones tied to lower cancer risk in diabetes patients

Pioglitazone, rosiglitazone linked to lower liver cancer risk; rosiglitazone tied to lower CRC risk.

Side effects of certain cancer drugs may be fatal

Sorafenib, sunitinib, and pazopanib have been found to carry a heightened risk of fatal complications, but the incidence remains low overall.

Mutations in IDH1/2 Seen in Intrahepatic Bile Duct Cancers

Mutations in IDH1/2 Seen in Intrahepatic Bile Duct Cancers

Mutations found in about a quarter of cholangiocarcinomas of intrahepatic origin.

ACS annual report says cancer mortality is decreasing

Cancer incidence rates in men declined by 0.6% per year and remained stable in women and cancer mortality fell by 1.8% per year for men and by 1.6% per year for women between 2004 and 2008.

Everolimus combination improved progression-free survival in neuroendocrine tumors

Progression-free survival improved in patients with advanced neuroendocrine tumors when everolimus rather than placebo was used in combination with octreotide long-acting repeatable.

Diabetes drug helps prevent growth of breast cancer cells

Metformin, a widely used agent in the treatment of type 2 diabetes, stopped a number of natural and man-made chemicals from stimulating the growth of breast cancer cells.

Cancer risk doubles for organ-transplant recipients

Compared with the general population, recipients of a kidney, liver, heart, or lung transplant have twice as great a risk for diverse infection-related and unrelated cancers.

Caffeine: The new sunblock?

Applying caffeine directly to the skin may eventually prove to help prevent sunlight-induced skin cancer, suggest the findings from a recent mouse study.

Radioembolization attains survival in liver cancer

A multicenter study conducted across Europe indicates that the liver-directed therapy, radioembolization, can be used to achieve survival in persons with hepatocellular carcinoma—including those with advanced disease and few treatment options.

Current alcohol consumption guidelines will not prevent cancer

An analysis published online by CMAJ charges that current guidelines for alcohol consumption are inadequate for cancer prevention and that new international guidelines are needed.

Experts discuss their predictions for radiation medicine

Experts discuss their predictions for radiation medicine

Presentations on emerging standards of care in radiotherapy from the Future of Radiation Medicine 2011 symposium are reviewed.

Celecoxib may be new weapon in fight against liver cancer

A cyclooxygenase-2 (COX-2) selective nonsteroidal anti-inflammatory drug (NSAID) usually prescribed to relieve arthritis pain appears to be an effective treatment for liver cancer.

Liver cancer linked to metabolic syndrome

People with metabolic syndrome may have heightened risks of developing hepatocellular carcinoma and intrahepatic cholangiocarcinoma, the two most common types of liver cancer.

Y-90 radioembolization extends life in liver cancer

Higher doses of yttrium-90 (Y-90) than previously used in intra-arterial radioembolization to treat persons with liver tumors provide results when chemotherapies have failed.

Overall cancer mortality rates decrease, but incidence of some cancers increases

Overall, cancer incidence rates fell approximately 1% annually and overall death rates decreased by an average of 1.6% annually between 2003 and 2007.

Gene target expands treatment prospects for liver cancer

The limited therapeutic options for hepatocellular carcinoma may have just broadened with the discovery of a new molecular target for the disease.

Protein may predict cancer metastasis

The presence of high levels of a particular protein in tumors drives metastasis, providing a valuable biomarker for predicting the spread of cancer.

Tumor ablation treatment: A review of modalities

Tumor ablation treatment: A review of modalities

These interventional oncology strategies are a new and promising group of minimally invasive alternatives to surgical resection of tumors.

Tumor ablation modalities: A review

Interventional oncology strategies are a new and promising group of minimally invasive alternatives to surgical resection of tumors.

Treatment beyond liver transplantation criteria may improve patient outcomes

Patients with liver cancer may benefit from treatment beyond transplantation criteria, according to a study published in Liver Transplantation (2010 Aug;16(8):925-9).

Patients with liver cancer may benefit from antiviral therapy

Antiviral therapy can prevent recurrence of hepatocellular carcinoma (HCC) and extend the lives of patients with chronic hepatitis B (CHB), according to a study conducted by researchers from the Division of Gastroenterology and Hepatology at Thomas Jefferson University.

Genomic tool may help identify patients with poor outcomes from liver cancer

Researchers have identified genetic signatures that may help predict liver cancer recurrence, according to a study presented at the Annual Meeting of the European Association for the Study of the Liver.

Obesity strongly promotes tumor growth in the liver

Researchers have identified a link between obesity and an increased risk of developing cancer, according to a study published in the journal Cell (2010;140[2]:197-208).

The effect on cancer risk of drinking a pint a day

Drinking a pint of beer, a large glass of wine or a couple of measures of spirits a day increases the risk of liver and bowel cancer by a fifth, according to researchers.

Case Study: Downstaging liver metastases in colorectal cancer

A 35-year-old woman presents with a one-day history of lower-right abdominal pain, setting the stage for chemotherapy for metastatic colorectal cancer

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