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LITHOSTAT
Miscellaneous urogenital disorders
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Drug Name:

LITHOSTAT Rx

Generic Name and Formulations:
Acetohydroxamic acid 250mg; tabs.

Company:
Mission Pharmacal Company

Therapeutic Use:

Indications for LITHOSTAT:

As adjunctive therapy in chronic urea-splitting urinary infection.

Adult:

Initially 12mg/kg per day every 6–8hrs; max 1.5g/day. Renal impairment: serum creatinine >1.8mg/dL: take at every 12-hour intervals; max 1g/day.

Children:

Initially 10mg/kg per day; monitor. Titrate doses to obtain therapeutic effects.

Contraindications:

Disease and physical state amenable to surgery and antimicrobials. Urine infected by non-urease producing organisms. Infections controllable by oral antimicrobials. Renal dysfunction (CrCl <20mL/min, serum creatinine >2.5mg/dL). Females with unsatisfactory method of contraception. Pregnancy (Cat.X).

Warnings/Precautions:

Severe renal impairment: monitor and consider reduced dose. Monitor liver function. Preexisting thrombophlebitis or phlebothrombosis. Monitor and obtain CBCs with reticulocytes after 2 weeks of therapy and every 3 months thereafter; if reticulocytes >6%, consider reduced dose. Nursing mothers: not recommended.

Interactions:

Rash with concomitant alcohol. Concomitant dietary iron: may reduce absorption of both acetohydroxamic acid and iron (use IM inj form, if needed).

Pharmacological Class:

Urease inhibitor.

Adverse Reactions:

Mild headaches, tremulousness, nervousness, depression, anxiety, GI upset, hemolytic anemia, mild reticulocytosis without anemia, rash, alopecia, phlebitis, palpitations.

How Supplied:

Tabs—100

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