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LIPOFEN
Hyperlipoproteinemias
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Drug Name:

LIPOFEN Rx

Generic Name and Formulations:
Fenofibrate 50mg, 150mg; caps.

Company:
Kowa Pharmaceuticals America, Inc.

Therapeutic Use:

Indications for LIPOFEN:

Adjunct to diet when response to nondrug therapy is inadequate in hypertriglyceridemia (Types IV and V), and to reduce elevated total-C, LDL-C, apo B, and TG, and to increase HDL-C, in primary hypercholesterolemia and mixed dyslipidemia (Type IIa and IIb).

Adult:

Take with food. Hypertriglyceridemia: 50–150mg/day, adjust at 4–8 week intervals; max 150mg/day. Hypercholesterolemia, dyslipidemia: 150mg/day. Renal impairment or elderly: initially 50mg/day. Discontinue if inadequate response after 2 months on max dose.

Children:

Not recommended.

Contraindications:

Hepatic dysfunction. Primary biliary cirrhosis. Severe renal dysfunction. Gallbladder disease.

Warnings/Precautions:

Renal impairment. Monitor CBCs for first year; monitor liver function; discontinue if ALT (SGPT) levels >3xULN persist. Discontinue if markedly elevated CPK levels, myopathy, gallstones, or severely depressed HDL levels occur. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Avoid statins. Potentiates oral anticoagulants (reduce anticoagulant dose and monitor PT/INR). Allow at least 1 hour before or 4–6 hours after bile acid sequestrants. Caution with immunosuppressants (eg, cyclosporine, tacrolimus), colchicine, other nephrotoxic drugs.

Pharmacological Class:

Fibrate.

Adverse Reactions:

Abnormal liver function tests, elevated CPK, respiratory or GI effects, myopathy, cholelithiasis, pancreatitis, rash; rare: rhabdomyolysis, transient hematologic changes, blood dyscrasias.

Generic Availability:

YES

How Supplied:

Caps—30, 90

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