Leukemia

New tool uses drug spillover to match cancer patients with treatments

New tool uses drug spillover to match cancer patients with treatments

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A new tool predicts what genetics are truly driving the cancer in any population of cells and helps the user choose the best kinase inhibitor to address the issue.

In refractory leukemia, IV busulfan plus cyclophosphamide may be a valid alternative

In refractory leukemia, IV busulfan plus cyclophosphamide may be a valid alternative

Intravenous busulfan plus cyclophosphamide may be a valid and efficient alternative for patients with refractory acute myeloid leukemia.

Patient-reported resilience associated with outcomes after HCT

Patient-reported resilience associated with outcomes after HCT

Among long-term survivors of hematopoetic cell transplantation (HCT), patient-reported resilience is independently associated with outcomes.

Expensive new leukemia medication to be covered by Medicare

Expensive new leukemia medication to be covered by Medicare

Amgen's Blincyto costs about 178,000 for a standard course of treatment.

Research breakthrough identifies how mutated genes reprogram blood stem cells in leukemia

Research breakthrough identifies how mutated genes reprogram blood stem cells in leukemia

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You research has shed light on the process by which mutated genes in leukemia reprogram blood stem cells and send them spiraling out of control.

Stem cell transplantation improves outcomes for children with rare form of leukemia

Stem cell transplantation improves outcomes for children with rare form of leukemia

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Greatly improved outcomes have been observed in using stem cell transplantation to treat patients with juvenile myelomonocytic leukemia (JMML), a rare form of blood cancer.

Disparities exist in survival among younger patients with acute leukemia

Disparities exist in survival among younger patients with acute leukemia

Disparities in treatment outcomes for younger patients with acute promyelocytic leukemia (APL) exist.

TKIs appear safe in patients with chronic myeloid leukemia, CKD

TKIs appear safe in patients with chronic myeloid leukemia, CKD

Tyrosine kinase inhibitors (TKIs) seem safe in patients with chronic myeloid leukemia (CML) in chronic-phase and chronic kidney disease.

New approach to treating B-cell acute lymphoblastic leukemia shows promise

New approach to treating B-cell acute lymphoblastic leukemia shows promise

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New compound that locks a disease-related protein into an inactive position stifled the growth of an aggressive form of leukemia.

Arthritis drug shows potential for blood cancer treatment

Arthritis drug shows potential for blood cancer treatment

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Scientists have discovered that a common drug given to arthritis sufferers could also help to treat patients with blood cancers.

Preclinical data shows promise for pediatric acute lymphoblastic leukemia

Preclinical data shows promise for pediatric acute lymphoblastic leukemia

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A recently developed drug holds great promise for some children with acute lymphoblastic leukemia (ALL).

Experimental treatment sends deadly leukemia into remission

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An experimental new treatment approach could buy patients with a rare and dangerous leukemia type the time to obtain a stem cell transplant.

Avocados may hold the answer to beating leukemia

Avocados may hold the answer to beating leukemia

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Can molecules derived from avocados be used as a tool to combat leukemia?

Hematologic cancer drug prices not cost-effective, may compromise patient adherence

Hematologic cancer drug prices not cost-effective, may compromise patient adherence

Majority of existing drugs for hematologic cancers are priced too high to be considered cost-effective in the United States.

Combining targeted drug with chemotherapy prolongs life for patients with B-cell lymphoma

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The combination of ibrutinib and chemotherapy (bendamustine and rituximab [BR]) was found to reduce the risk of death by nearly 80% in patients with previously treated CLL or SLL.

Attitudes, beliefs toward end-of-life care differ between hematologic, solid tumor specialists

Attitudes, beliefs toward end-of-life care differ between hematologic, solid tumor specialists

Survey compares attitudes and beliefs toward palliative care among hematologic versus solid tumor specialists.

Breastfeeding linked to lower childhood leukemia risk

Breastfeeding linked to lower childhood leukemia risk

One more potential benefit for breastfed babies, research suggests, is a lowered risk of childhood leukemia.

Internationally Applicable Prognostic Index for 5-Year OS Validated for Patients with CLL

Internationally Applicable Prognostic Index for 5-Year OS Validated for Patients with CLL

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A new meta-analysis of 26 factors has resulted in an internationally applicable prognostic index for patients with chronic lymphocytic leukemia, according to study results presented at 2015 ASCO Annual Meeting.

Targeting CD20 in chronic lymphocytic leukemia

Targeting CD20 in chronic lymphocytic leukemia

[Blood and Lymphatic Cancer: Targets and Therapy] The article discusses the history, use, and evolution of rituximab in the treatment of CLL and examines the next generation CD20 antibodies ofatumumab and obinutuzumab.

Transitioning High-Dose AML Chemo to Outpatient Setting Improves Quality of Life

Transitioning High-Dose AML Chemo to Outpatient Setting Improves Quality of Life

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Transitioning a long-standing intensive chemotherapy regimen for acute myeloid leukemia (AML) to the outpatient setting is safe and feasible.

Researchers develop potential drug for rare leukemia

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Researchers have developed a new drug that shows potential as a treatment for a rare type of acute leukemia, according to a recent study.

Study pinpoints genetic cause of increased leukemia risk

Study pinpoints genetic cause of increased leukemia risk

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A mutation of the gene ETV6 has been pinpointed as the heritable, genetic cause of acute lymphoblastic leukemia (ALL), according to a study.

Promising drug offers new paradigm for treating leukemia

Promising drug offers new paradigm for treating leukemia

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Researchers have developed a compound that delays leukemia in mice and kills leukemia cells in human tissue samples, which gives hope it could be used to improve regular leukemia therapy.

Use of pharmacokinetics to measure response in CML

Use of pharmacokinetics to measure response in CML

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What data are available concerning inter- and intrapatient variability in the pharmacokinetics of TKIs in chronic myeloid leukemia?

Measuring treatment response is essential to guiding leukemia treatment

Measuring treatment response is essential to guiding leukemia treatment

A measurement of the concentration of leukemia cells in patient bone marrow during the first 46 days of chemotherapy may allow for better matching of patients to the optimal intensity of chemotherapy.

Chromosomal rearrangement is key to progress against aggressive infant leukemia

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Current research indicates that a rare but aggressive subtype of pediatric acute lymphoblastic leukemia (ALL) has surprisingly few mutations beyond the chromosomal rearrangement that affects the MLL gene.

Childhood leukemia study reveals disease subtypes and new treatment options

Childhood leukemia study reveals disease subtypes and new treatment options

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Acute lymphoblastic leukemia (ALL) has been found to have two distinct subtypes, and evidence indicates that roughly 13% of ALL cases may be successfully treated with targeted drugs used in the treatment of lymphomas in adults.

Breastfeeding may decrease risk of pediatric acute lymphoblastic leukemia

Breastfeeding may decrease risk of pediatric acute lymphoblastic leukemia

Breastfeeding a child may reduce that child's risk of developing pediatric acute lymphoblastic leukemia (ALL).

Presence of protein marks toxicity in leukemia

Presence of protein marks toxicity in leukemia

Presence of this protein indicates a likely toxicity effect associated with chemotherapy in acute myeloid leukemia (AML).

Gene variant increases risk and severity of nerve disorder linked to vincristine

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Children with acute lymphoblastic leukemia with a certain gene variant experienced a higher incidence and severity of peripheral neuropathy after receiving treatment with the cancer drug vincristine, according to a study.

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