Leukemia

Good news for young patients with a leukemia subtype with poor prognosis

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For younger patients with an acute lymphoblastic leukemia (ALL) subtype, modifying treatment based on chemotherapy response can make a vital difference.

Novel drug safe for patients with leukemia

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Results of a phase I clinical trial showed that a new drug targeting mitochondrial function in human cancer cells was safe and showed some efficacy in a heavily pretreated cohort of patients.

For Ph-like acute lymphoblastic leukemia (ALL), tyrosine kinase inhibitors (TKIs) may be effective

For Ph-like acute lymphoblastic leukemia (ALL), tyrosine kinase inhibitors (TKIs) may be effective

Tyrosine kinase inhibitors (TKIs) may be effective for the treatment of acute lymphoblastic leukemia (ALL).

High-risk leukemia subtype becomes more common with age

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Many young adults with the most common form of acute lymphoblastic leukemia (ALL) have a high-risk subtype with a poor prognosis and could benefit from drugs used to treat other types of leukemia.

Weekend hospitalization linked to longer stays for pediatric patients with leukemia

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Weekend hospital admission for pediatric patients with newly diagnosed leukemia is associated with a longer length of stay, slightly longer wait to start chemotherapy, and higher risk for respiratory failure.

CPI-613 safe and somewhat efficacious for patients with leukemia

CPI-613 safe and somewhat efficacious for patients with leukemia

CPI-613 safe and somewhat efficacious for the treatment of patients with relapsed or refractory leukemia.

Natural killer cells battle pediatric leukemia

Natural killer cells battle pediatric leukemia

A select team of immune-system cells from patients with leukemia can be multiplied in the laboratory, creating a horde of natural killer cells that can be used to target and destroy the cancer cells.

Major breakthrough in understanding acute lymphoblastic leukemia

Major breakthrough in understanding acute lymphoblastic leukemia

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By analyzing the DNA sequence of patients at different stages of leukemia, researchers have discovered mutations in genes that lead to childhood leukemia of the acute lymphoblastic type, the most common childhood cancer.

Pediatric patients with leukemia have longer stay if admitted on weekend

Pediatric patients with leukemia have longer stay if admitted on weekend

Weekend admission for pediatric patients with leukemia associated with a longer length of stay.

Study explores reasons for significant variations in blood cancer survival across Europe

Study explores reasons for significant variations in blood cancer survival across Europe

The EUROCARE study, the largest population-based study of survival in European blood cancer patients to date, analyzed data from 30 cancer registries, involving all patients with cancer diagnoses in 20 European countries.

New test predicts survival in patients with leukemia

New test predicts survival in patients with leukemia

Scientists have developed a test which accurately predicts the prognosis for patients with the most common form of leukemia.

US Food and Drug Administration fast-tracks novel leukemia therapy

US Food and Drug Administration fast-tracks novel leukemia therapy

An experimental immunotherapy agent was placed on the US Food and Drug Administration's fast track to market approval after overwhelmingly positive results were seen in patients with leukemia. In early trials, 89% of patients who received the personalized immunotherapy known as CTL019 saw their cancers disappear.

Leukemia gene leads to potential target for triple-negative breast cancer treatment

Leukemia gene leads to potential target for triple-negative breast cancer treatment

Scientists have discovered that a gene previously linked to leukaemia could provide an urgently needed target for the development of drugs to treat patients with 'triple negative' breast cancer.

Game changer for leukemia therapy

Game changer for leukemia therapy

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Cancer cells decide whether to live or die after a short period of intense exposure to targeted therapy, opposing the current requirement for continuous treatment, according to a new study.

Restoring gene function reverses cancer in common childhood leukemia

Restoring gene function reverses cancer in common childhood leukemia

Researchers in Melbourne, Australia, have shown that switching off a gene called Pax5 could cause a type of leukemia, and restoring its function could cure the disease.

Nearly one-quarter of children in remission from ALL miss doses of maintenance medication

Nearly one-quarter of children in remission from ALL miss doses of maintenance medication

Children in remission from acute lymphocytic leukemia (ALL) must take 6-mercaptopurine (6MP) for 2 years to prevent disease reemergence; however, a study shows that an estimated 25% of children in remission are not taking this essential maintenance medication at least 90% of the time, tripling their relapse risk.

One cell's food is another cell's poison

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Loss of JAK2, a protein that can promotes the growth of cancer cells, causes healthy blood stem cells to disappear while cancer cells preserve their growth potential, according to research.

Novel target identified for chemotherapy-resistant leukemia cells

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By targeting a particular receptor, chemotherapy-resistant cancer cells can be killed in an acute form of childhood leukemia, according to new research.

Link between Down syndrome and leukemia discovered

Link between Down syndrome and leukemia discovered

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A team of investigators has uncovered a connection between Down syndrome and a heightened risk of developing acute lymphoblastic leukemia during childhood.

New experimental drug may be game-changer for acute myeloid leukemia

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Clinical trials for a new experimental drug, CPX-351, to treat acute myeloid leukemia are very promising, according to researchers.

Experimental drug promising for treatment-resistant leukemia

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The experimental compound dubbed TTT-3002 has been identified as a potent means to block genetic mutations in cancer cells blamed for some forms of treatment-resistant leukemia, according to research.

More sensitive testing may better define prognosis and treatment for leukemia

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Nearly half of patients with the most common form of adult leukemia may have a distinct pattern of genetic abnormalities that could better define their prognosis and treatment.

Chemotherapy-free treatment a possibility for leukemia/lymphoma

Chemotherapy-free treatment a possibility for leukemia/lymphoma

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Patients with terminal forms of leukemia and lymphoma who have run out of treatment options could soon benefit from a new drug, which not only puts an end to chemotherapy and has virtually no side effects.

Experts praise CLL trial for including elderly with coexisting conditions

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A German study of a new drug therapy for chronic lymphocytic leukemia was praised because the majority of the patients enrolled were elderly and had other, coexisting health issues.

Genetically modified T cells eradicate advanced leukemia

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The largest clinical study ever conducted to date of patients with advanced leukemia found that 88% achieved complete remission after being treated with genetically modified versions of their own immune cells.

Promising new approach discovered to treat leukemia

Promising new approach discovered to treat leukemia

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A group of researchers discovered a promising new approach to treating leukemia by disarming a gene that is responsible for tumor progression.

Complete recovery from hairy cell leukemia after vemurafenib treatment

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Vemurafenib, a BRAF inhibitor that has been approved as a treatment for advanced melanomas, has also proved successful in treating hairy cell leukemia.

Maternal coffee consumption tied to childhood leukemia

Maternal coffee consumption tied to childhood leukemia

Linear dose-response relationship for acute lymphoblastic leukemia and acute myeloid leukemia has been observed.

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