Leukemia

Antibody Therapy Reduces Numbers of Cancer Stem Cells in Patients With Multiple Myeloma

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Cancer stem cells that drive tumor growth were halved by MEDI-551, an experimental antibody treatment for multiple myeloma, according to results of a small preliminary clinical trial.

Idelalisib therapy of indolent B-cell malignancies: chronic lymphocytic leukemia and small lymphocytic or follicular lymphomas

Idelalisib therapy of indolent B-cell malignancies: chronic lymphocytic leukemia and small lymphocytic or follicular lymphomas

[Blood and Lymphatic Cancer: Targets and Therapy] This research examines the clinical trial data using idelalisib as monotherapy or in combination with rituximab for the treatment of indolent B-cell malignancies.

Targeted Therapies Suppress T-cell Response But Superagonist Can Overcome the Suppression

Targeted Therapies Suppress T-cell Response But Superagonist Can Overcome the Suppression

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Dozens of targeted therapies, which are preferred as treatment over chemotherapy and surgery, suppress the activity of T cells that could help to fight tumors.

Efficacy of First-line Ponatinib in CP-CML Remains Unclear

Efficacy of First-line Ponatinib in CP-CML Remains Unclear

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Ponatinib treatment was compared with imatinib in newly diagnosed patients with chronic myeloid leukemia in chronic phase (CP-CML).

Challenges faced in the treatment of acute lymphoblastic leukemia in adolescents and young adults

Challenges faced in the treatment of acute lymphoblastic leukemia in adolescents and young adults

[Clinical Oncology in Adolescents and Young Adults] This research reviews the outcomes with chemotherapy alone and with hematopoietic stem cell transplantation in acute lymphoblastic leukemia, and examines the challenges faced in determining the best therapy for the adolescents and young adult patient population.

Significant Reduction in Treatment Costs Are Anticipated With the Emergence of Generic TKI

Significant Reduction in Treatment Costs Are Anticipated With the Emergence of Generic TKI

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With the January 2016 expiration of the patent on Gleevac, significant cost savings can be realized by insurance companies and patients. Just 15 years ago, Gleevac (imatinib) changed chronic myeloid leukemia (CML) from a fatal disease to a treatable illness.

Gut Bacteria Could Reduce GVHD in Patients Undergoing Bone Marrow Transplantation

Gut Bacteria Could Reduce GVHD in Patients Undergoing Bone Marrow Transplantation

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A short-chain fatty acid made by bacteria in the gut could play an important role in GVHD after allogeneic bone marrow transplant in mice. In human patients who receive bone marrow transplants, GVHD can cause severe gut damage.

Research Results Bring Science One Step Closer to Creating Blood Stem Cells in the Laboratory

Research Results Bring Science One Step Closer to Creating Blood Stem Cells in the Laboratory

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New research has shed light on how the blood is produced in the body, and this work, done in mice, moves science a step closer to manipulation of blood stem cell creation. This could reduce the need for bone marrow transplants, such as those needed by patients with cancer.

New Possible Treatment Addresses Specific Type of Leukemia

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A subtype-specific weakness of T-cell acute lymphoblastic leukemia (T-ALL) could enable improved treatment, according to results from a a recent study using a mouse model.

Lymphocytosis Associated With Improved Survival in Dasatinib-treated Patients

Lymphocytosis Associated With Improved Survival in Dasatinib-treated Patients

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Lymphocytosis is associated with higher response rates, significantly longer response durations, and improved overall survival.

Hair, Nail Abnormalities Common With Ibrutinib Therapy

Hair, Nail Abnormalities Common With Ibrutinib Therapy

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Hair and nail abnormalities are commonly associated with the Bruton tyrosine kinase inhibitor ibrutinib.

Study Findings Show Possible Association Between PreLabor Cesarean Delivery and Risk for ALL in Young Children

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The finding that prelabor cesarean delivery may have a correlation with acute lymphoblastic leukemia (ALL) may offer new targets for research into preventing cancer.

Combination Improves Anticancer Activity of 2 Agents in Acute Myeloid Leukemia

Combination Improves Anticancer Activity of 2 Agents in Acute Myeloid Leukemia

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Combining birinapant with a p38 inhibitor is a promising therapeutic regimen for patients with acute myeloid leukemia (AML).

Patient Education Video an Effective Learning Tool, Provides Positive Experience

Patient Education Video an Effective Learning Tool, Provides Positive Experience

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Video-based patient education tool is an effective adjunct to printed materials and one-on-one counseling on post HSCT.

Early Lineage T Cells Are Better for Immunotherapy in Pediatric Patients With ALL and Lymphoma

Early Lineage T Cells Are Better for Immunotherapy in Pediatric Patients With ALL and Lymphoma

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Outcomes from a novel personalized cell therapy may be improved if specific subtypes of T cells are selected to attack diseases such as acute lymphoblastic leukemia and lymphoma.

Long-term Attention and Learning Deficits Persist After Chemotherapy for Pediatric Leukemia

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Pediatric survivors of ALL treated only with chemotherapy remain at an increased risk for attention problems 2 years after treatment cessation.

Chromosomal Rearrangements Initiate High-risk Leukemia

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Abnormal breakage and chromosomal rearrangement in white blood cells result in a particularly aggressive Philadelphia chromosome-like ALL, according to a new study.

Novel Technique Detects Persistent Leukemia in Patients Previously Thought to be in Remission

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Persistent chronic myeloid leukemia in patients previously thought to be in remission can be detected with digital polymerase chain reaction.

Direct Measures of Body Composition, not BMI, Needed to Track Obesity During Leukemia Treatment

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Change in BMI does not reflect body composition of patients undergoing treatment for ALL, suggesting direct measures of body composition should be used to evaluate obesity in patients with leukemia.

Darbepoetin Alfa Reduces Red Blood Cell Transfusions In Patients With Myelodysplastic Syndrome

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Darbepoetin alfa reduced the incidence of red blood cell transfusions in anemic patients with low and intermediate-1 risk myelodysplastic syndrome, according to phase 3 clinical trial data.

Chemotherapy-related Bone Loss in Children With ALL Occurs Earlier Than Previously Assumed

Chemotherapy-related Bone Loss in Children With ALL Occurs Earlier Than Previously Assumed

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Significant bone loss in children receiving chemotherapy for acute lymphoblastic leukemia (ALL) occurs during the first month of treatment.

Dasatinib, Nilotinib, Ponatinib Increase Vascular Occlusive Events

Dasatinib, Nilotinib, Ponatinib Increase Vascular Occlusive Events

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Dasatinib, nilotinib, and ponatinib, used in the treatment of patients with chronic myeloid leukemia (CML) increase vascular occlusive events.

Study Evaluates Gemtuzumab Ozogamicin in Older Patients With AML

Study Evaluates Gemtuzumab Ozogamicin in Older Patients With AML

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First-line monotherapy with low-dose gemtuzumab ozogamicin significantly improved overall survival compared with best supportive care.

Blood Test Could Help Predict Acute Myeloid Leukemia Recurrence

Blood Test Could Help Predict Acute Myeloid Leukemia Recurrence

A simple blood test can identify post-chemo patients with the NPM1 gene mutation.

Molecular Signature Predicts Transition from Myelodysplastic Syndrome to Acute Myeloid Leukemia

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Progress from myelodysplastic syndrome to AML is linked to the enzyme glycogen synthase kinase, and a molecular signature is found to predict clinical outcomes of patients with MDS.

Treatment-related Anxiety for Pediatric Patients with Acute Lymphoblastic Leukemia Examined

Treatment-related Anxiety for Pediatric Patients with Acute Lymphoblastic Leukemia Examined

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A new study examined levels of procedure-related anxiety in children with standard-risk acute lymphoblastic leukemia (ALL).

Antibody Therapy Beneficial for Patients With Leukemia Undergoing Stem Cell Transplant

Antibody Therapy Beneficial for Patients With Leukemia Undergoing Stem Cell Transplant

Results for patients with acute leukemia that received the antibody showed lower incidence of chronic graft-versus-host disease post-transplant.

Immunotherapeutic Agent Blocks Protein-Protein Interaction That Supports Chronic Lymphocytic Leukemia Growth and Metastasis

Immunotherapeutic Agent Blocks Protein-Protein Interaction That Supports Chronic Lymphocytic Leukemia Growth and Metastasis

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Wnt5a protein acts on a pair of tumor-surface proteins to accelerate the proliferation and spread of CLL. These effects of Wnt5a were blocked by a humanized monoclonal antibody called cirmtuzumab, according to a recent study.

Adolescents and Young Adults With Blood Cancers Experience Substantial Pyschological Morbidities

Adolescents and Young Adults With Blood Cancers Experience Substantial Pyschological Morbidities

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Adolescents and young adults (AYAs) with hematologic malignancies experience significant psychological morbidities during treatment and early survivorship.

Vitamin D Deficiency May Be Associated With Increased Risk of Leukemia

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People residing at higher latitudes, who are exposed to lower levels of sunlight/ultraviolet B light and have a higher prevalence of vitamin D deficiency, are at least twice as likely to develop leukemia than equatorial populations.

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