HCT-related Concerns at Discharge Associated With Depression

HCT-related Concerns at Discharge Associated With Depression
HCT-related Concerns at Discharge Associated With Depression

Hematopoietic cell transplantation (HCT)-related concerns at the time of hospital discharge predict increases in depression but not in anxiety, a study presented at the BMT Tandem Meetings 2016 in Honolulu, Hawaii, has shown.1

Although patient-reported outcomes have become increasingly more important to the daily care of HCT patients, there are limited data on the impact of transplant-related concerns on quality of life.

For the study, researchers enrolled 195 patients who underwent HCT, of which 49% received an autologous HCT and 51% received an allogeneic HCT. Participants completed questionnaires that evaluated their anxiety, depression, quality of life, and transplant-related concerns at hospital discharge, day 90, and day 180.

Results showed no differences in concerns between autologous HCT and allogeneic HCT at hospital discharge (P>.05), but patients who underwent allogeneic HCT reported significantly more concerns at day 90 (P<.05) than those who received autologous HCT.

Researchers found that transplant-related concerns at hospital discharge predicted increases in depression from hospital discharge to day 90 (P<.05); however, they did not predict changes in depression from hospital discharge to day 180 or changes in anxiety to day 90 or day 180 (all P>.05).

The study also demonstrated that particular concerns regarding retaining one's job, blurry eyesight, trouble concentrating, and reduced libido predicted increased in depression for hospital discharge to day 90 (P<.05).

“These findings highlight the importance of assessing patient concerns regarding HCT, particularly at hospital discharge, and emphasize the importance of performing large prospective clinical research on quality of life-related issues in HCT-recipients,” the authors conclude.


Barata A, Jim H, Martino R, et al. Transplant-related concerns at hospital discharge predict increases in depression. Poster presented at: BMT Tandem Meetings 2016; February 18-22, 2016; Honolulu, HI.

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs