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LAMISIL ORAL GRANULES
Fungal infections
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Drug Name:

LAMISIL ORAL GRANULES Rx

Generic Name and Formulations:
Terbinafine HCl 125mg, 187.5mg; per packet.

Company:
Novartis Pharmaceuticals Corp

Therapeutic Use:

Indications for LAMISIL ORAL GRANULES:

Tinea capitis.

Adult:

Not applicable.

Children:

<4yrs: not recommended. Sprinkle granules on pudding or other soft, non-acidic food and swallow (do not chew); do not use applesauce or fruit-based foods. ≥4yrs: Take once daily for 6 weeks. <25kg: 125mg/day. 25–35kg: 187.5mg/day. >35kg: 250mg/day.

Contraindications:

Chronic or active liver disease.

Warnings/Precautions:

Onychomycosis: confirm diagnosis with nail specimen. Pre-existing hepatic disease or renal impairment (CrCl <50mL/min): not recommended. Perform LFTs prior to and periodically during treatment. Discontinue if hepatic injury, progressive skin rash (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS), taste/smell disturbances, severe neutropenia (neutrophils ≤1000 cells/mm3), thrombotic microangiopathy occurs, or if lupus erythematosus is suspected. Monitor CBCs if immunodeficient. Pregnancy (Cat.B), nursing mothers: not recommended.

Interactions:

Potentiated by cimetidine. Antagonized by rifampin. May potentiate drugs metabolized by CYP2D6 (eg, tricyclic antidepressants, SSRIs, beta-blockers). May be potentiated by CYP2C9 and CYP3A4 inhibitors (eg, fluconazole, ketoconazole, amiodarone). Potentiates caffeine. Antagonizes cyclosporine.

See Also:

LAMISIL TABLETS

Pharmacological Class:

Allylamine antifungal.

Adverse Reactions:

Headache, diarrhea, rash, dyspepsia, liver enzyme abnormalities, pruritus, taste disturbances, nausea, abdominal pain, flatulence, urticaria; also children: nasopharyngitis, pyrexia, cough, upper respiratory infection; rare: hepatotoxicity, depressive symptoms, smell disturbances.

How Supplied:

Tabs—30, 100; Packets—14, 42

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