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Lactulose solution
Hepatic encephalopathy
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Drug Name:

Lactulose solution Rx

Generic Name and Formulations:
Lactulose 10g/15mL; soln; for oral or rectal administration.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Lactulose solution:

Prevention and treatment of portal-systemic encephalopathy, including the stages of hepatic pre-coma and coma.

Adult:

Oral: 30–45mL 3–4 times daily; may adjust dose every day or two to produce 2–3 soft stools daily. Hourly doses of 30–45mL may be used to induce rapid laxation initially; when laxative effect has been achieved, reduce dose to recommended daily dose. Maintenance: continue recommended daily dose. Rectal: may be given as a retention enema via a rectal balloon catheter. Mix 300mL of lactulose solution with 700mL of water or physologic saline, retain for 30–60 minutes. May repeat every 4–6 hours; if evacuated too promptly, may be repeated immediately. Start oral route before stopping enema entirely.

Children:

Oral: Individualize dose to produce 2–3 soft stools daily. Infants: initially 2.5–10mL in divided doses. Older children and adolescents: 40–90mL/daily. If initial dose causes diarrhea, reduce dose immediately; discontinue if diarrhea persists.

Contraindications:

Patients who require a low galactose diet.

Warnings/Precautions:

Perform thorough bowel cleansing with non-fermentable solution prior to electrocautery procedures during proctoscopy or colonoscopy. Diabetes. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Avoid concomitant laxatives. Caution with concomitant oral anti-infectives (eg, neomycin); monitor closely. May be antagonized by non-absorbable antacids.

Pharmacological Class:

Colonic acidifier.

Adverse Reactions:

Gas, cramping, diarrhea, nausea, vomiting; infants: also hyponatremia, dehydration.

Note:

Formerly known under the brand names Cephulac, Chronulac, Evalose.

How Supplied:

Contact supplier.

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