LabMed

Low Serum Cortisol

Differential Diagnosis

Primary adrenal insufficiency

Secondary adrenal insufficiency with underlying disorder

Suggested Additional Lab Testing

Primary adrenal insufficiency

  • Exogenous ACTH does not stimulate cortisol secretion, and the plasma ACTH is elevated.

  • Serum aldosterone is low in cases in which destruction of the adrenal gland affects both cortisol and aldosterone production.

  • Testing for antibodies against the adrenal cortex may reveal autoimmune adrenalitis as a cause of primary adrenal insufficiency.

Secondary adrenal insufficiency

  • Low plasma ACTH, because the disorder originates in the hypothalamus or pituitary.

  • Serum aldosterone is often normal but may be decreased if there is significant atrophy of the adrenal gland as a result of chronic lack of stimulation by ACTH.

  • CRH stimulation test can distinguish between ACTH deficiency from pituitary and deficiency of CRH from hypothalamus.

You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs