LabMed

Increased Serum Aldosterone

Differential Diagnosis

Primary hyperaldosteronism

Secondary hyperaldosteronism

Suggested Additional Lab Testing

Primary hyperaldosteronism

  • Serum potassium is usually low, but a low-sodium diet may result in a normal value.

  • Serum sodium is mildly elevated in most cases.

  • Plasma renin activity is low for most cases of hyperaldosteronism.

  • The low value for plasma renin makes the ratio of serum aldosterone to plasma renin very elevated in primary hyperaldosteronism.

Secondary hyperaldosteronism

  • Serum potassium is usually low, but a low-sodium diet may result in a normal value.

  • Normal to mildly elevated serum sodium

  • Plasma renin activity is elevated when there is decreased perfusion of the kidneys, a common cause of secondary hyperaldosteronism

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