Abnormal Platelet Aggregation Studies
Acquired causes of platelet dysfunction:
Ingestion of aspirin or aspirin-like compounds or NSAIDs
Impaired renal function
Exposure to cardiopulmonary bypass
Presence of a paraprotein
Congenital causes of platelet dysfunction:
Storage pool disease
Disorders of thromboxane production or action
Suggested Additional Lab Testing
Platelet aggregation studies with characteristic response patterns for the different agonists help identify Glanzmann thrombasthenia, Bernard-Soulier disease, aspirin ingestion, and defects in thromboxane production or action.
Plasma or serum BUN and creatinine and urinalysis to assess renal function should be ordered.
If aspirin ingestion is suspected but denied by patient, measurement of salicylates (metabolites of aspirin) may prove useful.
Bone marrow biopsy may be useful if myeloproliferative disease is suspected.
Serum protein electrophoresis can reveal a paraprotein. To identify platelet granule storage pool disease, assays for the granular contents of platelets can be performed, but these are complex, costly, and rarely performed.
Copyright © 2017, 2013 Decision Support in Medicine, LLC. All rights reserved.
No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM.
- Cholesterol-Lowering Drugs May Prevent Breast Cancer Recurrence
- Idelalisib Increases Progression-Free Survival in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia
- Some Early Breast Cancer Patients Should Have Breast Conservation Instead of Mastectomy
- BBD Regimen Efficacious as First-line Therapy for Myeloma
- Trends in Behaviors, Medical Practice Indicate Mortality From Melanoma Will Decline
- Survivors Reporting Chronic Neuropathic Pain Struggle to Retain Jobs
- Timing of Chemotherapy Infusion Affects Inflammatory Response to Chemotherapy
- Postoperative Gemcitabine Plus Capecitabine: A New Standard of Care for Pancreatic Cancer
- Blood-Forming Stem Cell Transplants (Fact Sheet)
- Nut Consumption Inversely Associated With Lung Cancer Risk
- Targeting AR Mutations Promising in Metastatic Prostate Cancer
- GUCS 2017: Early Immunotherapy Discontinuation in mRCC
- Pembrolizumab Active Against Rare Melanoma, Extends Survival in Bladder Cancer
- Myalgia-arthralgia Syndrome Associated With Taxanes in Patients with Breast Cancer
- Women Treated for DCIS Have Slightly Lower Risk for All-Cause Mortality
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|