Abnormal Liver Function Tests: Elevations in ALT and AST, Which Predominate Over Elevations of Alkaline Phosphatase (ALP), 5'-NT, and/or Gamma Glutamyltransferase (GGT)
If the diseases in the list below increase in severity, there may be findings suggestive of cirrhosis with or without hepatic failure:
Viral hepatitis, multiple forms (see chapters on Viral Hepatitis A, B, and C)
Suggested Additional Lab Testing
Total bilirubin and unconjugated bilirubin are markedly elevated in hepatic failure.
Prothrombin time is elevated as a result of decreased synthesis of coagulation factors.
Aminotransferase levels may increase and then decrease rapidly when there is significant and permanent loss of hepatocytes.
Serum creatinine may be elevated as evidence of hepatorenal syndrome.
Low blood glucose, elevated white blood cell (WBC) count, low platelet count, and low serum albumin are also common in hepatic failure.
Serum ceruloplasmin is low (90% of the serum copper is complexed to this protein).
Twenty-four-hour urinary copper excretion is elevated.
Liver function tests may be normal, but, as the disease progresses, abnormal values appear.
Serum copper is usually elevated but may be normal or low.
Hepatic copper concentration is markedly elevated because of the low amount of serum ceruloplasmin; an elevated hepatic copper concentration is highly indicative of Wilson disease.
Serum alpha-1-antitrypsin level is low.
Abnormal liver function tests are detectable in adults who suffer liver damage, but they may be normal in early stages of disease.
Liver biopsy can show characteristic red cytoplasmic granules demonstrable by a PAS stain of the liver. Hepatocellular carcinoma requires histopathologic examination of a liver biopsy for diagnosis.
Copyright © 2017, 2013 Decision Support in Medicine, LLC. All rights reserved.
No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM.
- Novel Blood Test Detects Cancer, Locates Tumor Without Invasive Procedures
- Cabozantinib Activates Innate Immune Response, Eliminating Prostate Cancer
- Shorter Treatment of Breast Cancer with Trastuzumab May Lead to Improved Results
- Colorectal Cancer Rates Increased Sharply Among Generation X and Millennials
- Pneumonia Associated With Common Cold May Cause Fatal Illness in Stem Cell Transplant Recipients
- Early Palliative Care Reduced ICU Use in Patients With Advanced Cancer
- Ginger Extract Raises Antioxidant Levels in Patients Undergoing Chemotherapy
- Nurse Navigators Improve Physician Engagement in Pretreatment Discussions
- Screening Increases Early Palliative Care, Reduces Aggressive EOL Measures
- Antiperspirants/Deodorants and Breast Cancer (Fact Sheet)
- Genome Sequencing Explains Resistance to CTLA-4 and PD-1 Inhibitors in Metastatic Melanoma
- Lifestyle Choices Have Greater Influence on Colon and Rectal Cancer Risk
- Kidney Cancer Metastases in Lung May Hide Undiagnosed Primary Lung Cancer
- Nasal Biomarker in Smokers Could Predict Lung Cancer
- Arm Lymphoscintigraphy After Axillary Lymph Node Dissection or Sentinel Lymph Node Biopsy in Breast Cancer
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|