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Labetalol HCl Tablets
Hypertension
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Drug Name:

Labetalol HCl Tablets Rx

Generic Name and Formulations:
Labetalol HCl 100mg, 200mg, 300mg; scored tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Labetalol HCl Tablets:

Hypertension.

Adult:

Individualize. Initially 100mg twice daily. Titrate at 2–3 day intervals in increments of 100mg twice daily. Usual maintenance: 200–400mg twice daily; max 2.4g/day.

Children:

Not recommended.

Elderly:

Usual maintenance: 100–200mg twice daily.

Contraindications:

Asthma. 2nd- or 3rd-degree AV block. Overt cardiac failure. Cardiogenic shock. Severe bradycardia, other conditions associated with prolonged or severe hypotension.

Warnings/Precautions:

History of heart failure; withdraw gradually if cardiac failure continues despite adequate digitalization and diuretic. Monitor hepatic function; discontinue at first sign of liver injury. COPD. Pheochromocytoma. Diabetes. Surgery. Avoid abrupt cessation (ischemic heart disease may be exacerbated). Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Caution with verapamil. Potentiates hypotension with nitroglycerin. May block epinephrine, β-agonist bronchodilators. Adjust antidiabetic medication. Potentiated by cimetidine. Tremor with tricyclic antidepressants. Synergism with halothane; do not use high concentrations.

Pharmacological Class:

Noncardioselective beta-blocker/alpha-1 blocker.

Adverse Reactions:

Dizziness, GI upset, fatigue, nasal stuffiness, ejaculation failure, headache, dyspnea, vertigo, rash, orthostatic hypotension, edema, heart failure, bronchospasm, jaundice.

Note:

Formerly known under the brand names Normodyne, Trandate.

How Supplied:

Contact supplier.

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