Kaposi sarcoma of the mouth
Labial & Gingival Kaposi Sarcoma
This HIV patient presented with labial and gingival Kaposi sarcoma secondary to his AIDS infection which included the maxilla.
This is an advanced Kaposi sarcoma lesion of the soft palate. KS is different from most other forms of cancer in that it can develop at a number of different sites simultaneously rather than in a single site. The digestive system, which includes the oral cavity, is a usual site of development.
Oral Signs of Disease
Approximately 7.5% to 10% of AIDS patients display signs of oral Kaposi sarcoma. The lesions can range in appearance from small, asymptomatic growths that are flat purple-red in color, to larger nodular growths.
Raised, Darker Lesion
This image shows an intraoral KS lesion with an overlying candidiasis infection. Initially, KS lesions are flattened and red, but as they age they become raised and darker, tending to have a purple coloration.
This micrograph depicts the histopathologic changes found in a biopsied lymph node indicative of a Kaposi sarcomatous lesion from a patient with AIDS. The histopathology revealed in this slide includes characteristic erythrocyte-filled, slit-like spaces, and occasional cells containing globules.
This patient has intraoral Kaposi sarcoma of the hard palate.
AIDS Patient with Kaposi Sarcoma
Secondary to his AIDS infection, this patient displayed a moderately advanced Kaposi sarcoma lesion of the soft palate.
Photomicrograph of a Cutaneous Biopsy
This photomicrograph of a cutaneous biopsy shows Kaposi sarcoma at a medium magnification. The dermis contains a dense cellular infiltrate, and narrow slit-like vascular spaces that are characteristic in these KS lesions.
Kaposi sarcoma (KS) is a type of cancer in which patches of abnormal tissue grow under the skin or mucous membranes in the mouth, nose, and anus. The cancer can also involve the lungs, GI tract, and other organs. Kaposi sarcoma tumors usually manifest as bluish-red or purple bumps. It is common for the lesions to first appear on the feet, ankles, thighs, arms, hands, face, or other parts of the body, but they can also occur on sites inside the body. Other symptoms of the disease may include bloody sputum and shortness of breath.
Before the AIDS epidemic, Kaposi sarcoma was rare, progressed slowly, and was mainly seen in older men, organ transplant patients, or African men. In patients with AIDS, the cancer moves quickly and can be deadly; in these individuals, the disease is caused by an interaction between HIV, a weakened immune system, and the human herpesvirus-8 (HHV-8). People who have organ or kidney transplants also have an increased risk of Kaposi sarcoma.
Treatment of Kaposi sarcoma is dependent on how much the immune system is weakened, the number and location of tumors, and symptoms. Options for treatment include antiviral therapy if AIDS is present, combination chemotherapy, cryotherapy, or radiation therapy. Many patients experience tumor recurrence even after being treated.
All images courtesy of CDC / Sol Silverman, Jr., DDS, and Dr. Edwin P. Ewing, Jr.
Sign Up for Free e-newsletters
- Choice of Breast Reconstruction After Mastectomy Affects Satisfaction, Quality of Life
- Bariatric Surgery Reduced Risk of Some Cancers in Obese Patients
- Carfilzomib Benefits May Outweigh Cardiovascular Risk in Multiple Myeloma
- The Caregivers' Cancer Journey
- Genetic Link Between Depression and Breast Cancer Remains Unclear
- Implementing an Ambulatory Adherence Program May Improve Oral Anticancer Medications Compliance
- Exercise Habits Influence Mortality in Adult Survivors of Childhood Cancer
- Managing Dyspnea With Fentanyl in Patients With Cancer at End of Life
- CALM: A Depression Intervention for Cancer Patients at the End of Life
- High BMI Among Premenopausal Women May Improve Risk for Breast Cancer
- Fertility Preservation in Hodgkin's Lymphoma Patients That Undergo Targeted Molecular Therapies: An Important Step Forward From the Chemotherapy Era
- Survey of ACEP Councilors Reveals NP, PA Staffing Models, Practice Patterns Vary
- Breath Analysis May Be an Effective Diagnostic for Pancreatic Cancer
- Genetic Susceptibility to Pancreatic Cancer Linked to 6 Specific Gene Mutations
- Dinner Hour and Sleep Habits Affect Risk of Breast, Prostate Cancers
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|