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JANUVIA
Diabetes
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Drug Name:

JANUVIA Rx

Generic Name and Formulations:
Sitagliptin (as phosphate) 25mg, 50mg, 100mg; tabs.

Company:
Merck & Co., Inc.

Therapeutic Use:

Indications for JANUVIA:

Adjunct to diet and exercise in type 2 diabetes, as monotherapy or combination therapy.

Limitations Of use:

Not for treatment of type 1 diabetes or diabetic ketoacidosis. Not studied in patients with history of pancreatitis.

Adult:

100mg once daily. Renal insufficiency: CrCl ≥30–50mL/min: 50mg once daily; CrCl<30mL/min or on dialysis: 25mg once daily.

Children:

<18yrs: not established.

Warnings/Precautions:

Assess renal function before starting therapy and periodically thereafter. Consider risks/benefits in patients with known risk factors for heart failure; monitor for signs/symptoms; evaluate and consider discontinuing if develops. Monitor for signs/symptoms of pancreatitis, serious hypersensitivity reactions, severe joint pain, or bullous pemphigoid; discontinue if suspected or occurs. History of angioedema to other DPP-4 inhibitors. Severe hepatic insufficiency. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:

May need lower dose of concomitant sulfonylurea or insulin to reduce risk of hypoglycemia. Monitor digoxin.

Pharmacological Class:

Dipeptidyl peptidase-4 (DPP-4) inhibitor.

Adverse Reactions:

Upper respiratory tract infection, nasopharyngitis, headache; pancreatitis, heart failure, hypersensitivity reactions (eg, anaphylaxis, angioedema, Stevens-Johnson syndrome), severe and disabling arthralgia, bullous pemphigoid.

Generic Availability:

NO

How Supplied:

Tabs 25mg, 50mg—30, 90, 100; 100mg—30, 90, 100, 1000

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