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Isosorbide dinitrate
Angina
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Drug Name:

Isosorbide dinitrate Rx

Generic Name and Formulations:
Isosorbide dinitrate 2.5mg, 5mg; sublingual tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Isosorbide dinitrate:

Prophylaxis and treatment (in patients that do not respond to sublingual nitroglycerin) of angina.

Adult:

2.5–5mg sublingually 15 mins before activity; allow a daily dose-free interval of at least 14hrs.

Children:

Not established.

Contraindications:

Concomitant PDEIs (eg, sildenafil, tadalafil, vardenafil), riociguat.

Warnings/Precautions:

Recent MI. CHF. Hypotension. Volume depletion. Hypertrophic cardiomyopathy. Tolerance may develop. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

See Contraindications. Severe hypotension with sildenafil. Hypotension potentiated with alcohol, other vasodilators, calcium channel blockers.

See Also:

ISORDIL TITRADOSE

Pharmacological Class:

Nitrate.

Adverse Reactions:

Headache, orthostatic hypotension, paradoxical bradycardia.

Note:

Sublingual tabs formerly known under the brand names Isordil, Sorbitrate.

Generic Availability:

Titradose (YES)

How Supplied:

Sublingual—contact supplier; Titradose—100

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