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IOPIDINE
Glaucoma
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Drug Name:

IOPIDINE Rx

Generic Name and Formulations:
Apraclonidine (as HCl) 0.5%; oph. soln; contains benzalkonium chloride.

Company:
Alcon Laboratories, Inc.

Therapeutic Use:

Indications for IOPIDINE:

Short-term adjunctive therapy to reduce elevated IOP.

Adult:

Remove contact lenses; may reinsert 15min after instillation. 1–2 drops 3 times daily. Allow at least 5min between instillation of other oph drugs.

Children:

Not established.

Contraindications:

Clonidine allergy. Concomitant MAOIs.

Warnings/Precautions:

Monitor visual fields. Severe uncontrolled cardiovascular disease, hypertension, coronary insufficiency. Recent myocardial infarction. Cerebrovascular disease. Raynaud's syndrome. Thromboangiitis obliterans. Discontinue if ocular allergic-like reactions occur. Renal or hepatic impairment: closely monitor cardiovascular parameters. Depression. Masks hypoglycemia. Pregnancy. Nursing mothers.

Interactions:

Hypertensive crisis with MAOIs. May potentiate CNS depressants, alcohol. May be antagonized by tricyclic antidepressants. Additive hypotensive effects with neuroleptics; hypotensive and pulse effects with β-blockers, antihypertensives, cardiac glycosides, others (eg, clonidine).

Pharmacological Class:

Alpha-2 agonist.

Adverse Reactions:

Hyperemia, pruritus, dry mouth, itching, discomfort, tearing, dizziness, solmnolence, lid edema, blurred vision, foreign body sensation, dry eye, conjunctivitis, discharge, blanching, headache, asthenia, dry nose, taste perversion; tachyphylaxis may develop after 1 month.

Generic Availability:

YES

How Supplied:

Soln—5mL, 10mL

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