Imatinib

Safety of combining imatinib and radiotherapy

Safety of combining imatinib and radiotherapy

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Is combination therapy of imatinib (Gleevec) and radiotherapy safe?

Adjuvant imatinib promising for failure-free survival in GIST

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Adjuvant imatinib impacts short-term free from relapse in patients with localized, surgically resected, high/intermediate-risk gastrointestinal stromal tumors (GIST), according to interim results of an intergroup trial.

DNA-repair problems destroy hardy leukemia cells

Leukemia stem cells that overcome drug therapy can be thwarted when deprived of RAD52, a protein key to DNA repair of these cancer cells.

Oral therapy: Managing side effects can aid adherence

Oral therapy: Managing side effects can aid adherence

Diligent patient education that addresses adherence and persistence issues can optimize outcomes in patients with gastrointestinal stromal tumors.

Regorafenib prolongs survival in face of GI cancers

Persons with metastatic colorectal cancer or gastrointestinal stromal tumors may garner some survival benefit from regorafenib after standard treatments have failed.

Investigational drug is active against the most resistant types of chronic myeloid leukemia

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A previously invincible mutation in chronic myeloid leukemia has been thwarted by the investigational drug, ponatinib, in a phase I clinical trial.

Targeted drug overcomes resistance in patients with rare sarcoma

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Regorafenib, a new, targeted, oral drug, demonstrated the ability to control metastatic GIST, an uncommon and life-threatening form of sarcoma, after the disease had become resistant to all existing therapies.

Synergy of two drugs may treat imatinib-resistant chronic myeloid leukemia

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Danusertib and bosutinib work together to overcome resistance to imatinib for chronic myeloid leukemia (CML) with mutated BCR-ABL gatekeeper genes. The BCR-ABL mutation confers resistance to all currently approved kinase inhibitors for chronic myeloid leukemia.

The role of sunitinib in the treatment of GIST

The role of sunitinib in the treatment of GIST

What is the role of sunitinib malate in the treatment of sarcomas?

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