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Hydrochlorothiazide
Edema
Hypertension
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Drug Name:

Hydrochlorothiazide Rx

Generic Name and Formulations:
Hydrochlorothiazide 25mg, 50mg; scored tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Hydrochlorothiazide:

Edema.

Adult:

25–100mg daily in single or divided doses; may give on intermittent schedule (every other day or 3–5 days/wk).

Children:

See full labeling. 1–2mg/kg per day in 1 or 2 divided doses. <6 months: up to 3mg/kg per day in 2 divided doses. ≤2yrs: max 37.5mg/day. 2–12yrs: up to 100mg/day.

Contraindications:

Anuria. Sulfonamide allergy.

Warnings/Precautions:

Renal or hepatic impairment. Arrhythmia. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). K+ supplements or K+ sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. NSAIDs may cause renal failure. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. Hyperglycemia, hyperuricemia more likely with diazoxide. Antagonized by NSAIDs. May potentiate nondepolarizing muscle relaxants. May antagonize norepinephrine. May interfere with parathyroid tests.

Pharmacological Class:

Diuretic (thiazide).

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.

Note:

Formerly known under the brand names Esidrix, Hydro-D, Hydrodiuril, Microzide.

How Supplied:

Contact supplier.

Indications for Hydrochlorothiazide:

Hypertension.

Adult:

Initially 25mg once daily; usual max 50mg/day in single or divided doses.

Children:

See full labeling. 1–2mg/kg per day in 1 or 2 divided doses. <6 months: up to 3mg/kg per day in 2 divided doses. ≤2yrs: max 37.5mg/day. 2–12yrs: up to 100mg/day.

Contraindications:

Anuria. Sulfonamide allergy.

Warnings/Precautions:

Renal or hepatic impairment. Arrhythmia. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). K+ supplements or K+ sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. NSAIDs may cause renal failure. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. Hyperglycemia, hyperuricemia more likely with diazoxide. Antagonized by NSAIDs. May potentiate nondepolarizing muscle relaxants. May antagonize norepinephrine. May interfere with parathyroid tests.

Pharmacological Class:

Diuretic (thiazide).

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.

Note:

Formerly known under the brand names Esidrix, Hydro-D, Hydrodiuril, Microzide.

How Supplied:

Contact supplier.

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