Herbal carcinogen linked to urothelial cancer in Taiwan

Share this article:
Herbal Carcinogen Linked to Urothelial Cancer in Taiwan
Herbal Carcinogen Linked to Urothelial Cancer in Taiwan

(HealthDay News) -- A carcinogen produced by Aristolochia plants, which are commonly used in herbal remedies in Taiwan, is associated with signature types of DNA damage linked to aristolochic acid in Taiwanese patients with urothelial carcinoma of the upper urinary tract (UUC), according to a study published online April 9 in the Proceedings of the National Academy of Sciences.

Noting that aristolochic acid is known to be toxic and carcinogenic to the kidney, Chung-Hsin Chen, from the National Taiwan University Hospital in Taipei, and colleagues examined biomarkers associated with UUC in 151 UUC patients and 25 patients with renal cell carcinoma as controls; all patients lived in Taiwan. The authors note that the incidence of UUC in Taiwan is the highest in the world.

The researchers found that patients with UUC had a unique mutational signature in the TP53 tumor suppressor gene, including A:T to T:A transversion, that was identical to the signature found in Balkan endemic nephropathy, which is linked to ingestion of Aristolochia clematitis in wheat. These transversions were also found in the FGFR3 and HRAS oncogenes, in activating positions. Aristolactam-DNA adducts were found in the renal cortex of 83 percent of patients with A:T to T:A mutations in any of these genes.

"We conclude that exposure to aristolochic acid contributes significantly to the incidence of UUC in Taiwan, a finding with significant implications for global public health," Chen and colleagues write.

One author is an employee of Roche Molecular Systems, where the Amplichip p53 test used in this study is being developed.

Abstract
Full Text

This article originally appeared here.
Share this article:
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs

More in Daily Oncology News

Poor staging linked to mortality in bladder cancer

Poor staging linked to mortality in bladder cancer

In cases of bladder cancer, omission of muscle in specimen or its mention in pathology report is linked to increased mortality.

Daily aspirin may lower mortality in nonmetastatic prostate cancer

Daily aspirin may lower mortality in nonmetastatic prostate ...

Even a small daily dose of aspirin may help lower mortality among men with nonmetastatic prostate cancer, according to research.

Irinotecan plus bevacizumab ups outcome for metastatic colorectal cancer (CRC)

Irinotecan plus bevacizumab ups outcome for metastatic colorectal ...

Findings show benefits compared with FOLFIRI for patients with untreated metastatic disease.