Hematologic Malignancies

Defibrotide an Effective Option for SOS/VOD in Patients Undergoing HSCT

Defibrotide an Effective Option for SOS/VOD in Patients Undergoing HSCT

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Sinusoidal obstruction syndrome (or hepatic veno-occlusive disease), a complication observed in patients who undergo HSCT, is managed with defibrotide. In this study, investigators assessed its efficacy and patient response to therapy.

Complications and Management of Coagulation Disorders in Leukemia Patients

Complications and Management of Coagulation Disorders in Leukemia Patients

[Blood and Lymphatic Cancer: Targets and Therapy] Investigators conduct 4 case studies that illustrate a range of coagulation disorders that can develop in patients with leukemia to elucidate the rationale and process of specific treatment options.

A Case of Newly Diagnosed PCV After Relapse TTP Complicated by Undiagnosed RA

A Case of Newly Diagnosed PCV After Relapse TTP Complicated by Undiagnosed RA

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This case of a 63-year-old African American male with a complicated history illustrates the need for a comprehensive risk assessment of thrombosis in patients with primary polycythemia vera, especially those with concomitant conditions that predispose to thrombosis.

Dapsone, Danazol, Hydroxychloroquine Are Potential Second-line Options in ITP

Dapsone, Danazol, Hydroxychloroquine Are Potential Second-line Options in ITP

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A retrospective analysis of 28 studies determined that overall response rates for patients with ITP were similar treated with hydroxychloroquine, danazol, or dapsone in the second-line setting were similar.

Rituximab vs Splenectomy: Response Similar in Immune Thrombocytopenic Purpura

Rituximab vs Splenectomy: Response Similar in Immune Thrombocytopenic Purpura

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Results of a retrospective single-center study showed that response to rituximab vs splenectomy as second-line therapy for steroid-refractory ITP was not significantly different between the 2 treatments.

Combination of Western Care With Chinese Medicine Shows Potential in ITP

Combination of Western Care With Chinese Medicine Shows Potential in ITP

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The pathogenesis of idiopathic thrombocytopenic purpura (ITP) may be associated with Th17 helper T cells.

Role of Polymorphisms in Idiopathic Thrombocytopenic Purpura: A Review

Role of Polymorphisms in Idiopathic Thrombocytopenic Purpura: A Review

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The main cause of ITP remains unidentified; however, researchers suggest that certain polymorphisms in respective genes are potential factors for ITP.

Rare Case of Langerhans Cell Histiocytosis With Prior ITP Highlights Diagnostic Challenge for Clinicians

Rare Case of Langerhans Cell Histiocytosis With Prior ITP Highlights Diagnostic Challenge for Clinicians

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A rare case of Langerhans cell histiocytosis (LCH) in a patient with idiopathic thrombocytopenic purpura (ITP) highlights the difficulty in diagnosing LCH.

Navigating Patients With Hematologic Cancers

Navigating Patients With Hematologic Cancers

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An effective nurse navigator approach involves removing barriers to good care, such as differences in health care delivery systems, poor communication, and financial impediments.

Lack of Transfusion Services a Barrier to Hospice Care for Patients With Blood Cancers

Lack of Transfusion Services a Barrier to Hospice Care for Patients With Blood Cancers

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A lack of needed transfusion services was cited as why many hematologic oncologists are less likely to refer their patients with blood cancers to home hospice care.

IL-11 Plus Glucocorticoids Safe, Effective for ITP in Adults

IL-11 Plus Glucocorticoids Safe, Effective for ITP in Adults

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Recent study results demonstrate that recombinant IL-11 with glucocorticoids is a safe and effective treatment for idiopathic thrombocytopenic purpura (ITP) in adults.

Eradication of Infection Improves Outcomes for <i>H Pylori+</i> patients with ITP

Eradication of Infection Improves Outcomes for H Pylori+ patients with ITP

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Approximately 40% of ITP cases are caused by gram-negative H pylori infection; therefore, researchers sought to determine the effectiveness of infection eradication on platelet count in these patients.

Guideline-driven Initiative Improves Pneumococcal Vaccination Rates Among aHSCT Recipients

Guideline-driven Initiative Improves Pneumococcal Vaccination Rates Among aHSCT Recipients

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A nurse-led team developed a tracking tool that created a vaccination schedule from transplant date forward for autologous hematopoietic stem cell transplant recipients.

Novel Approach Prevents GVHD After Hematopoietic Stem Cell Transplantation

Novel Approach Prevents GVHD After Hematopoietic Stem Cell Transplantation

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An international team developed an approach to hematopoietic stem cell transplantation that prevents GVHD while preserving the benefits of the therapy.

Importance of GM-CSF Autoantibodies in Pulmonary Alveolar Proteinosis With MPN

Importance of GM-CSF Autoantibodies in Pulmonary Alveolar Proteinosis With MPN

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A case of simultaneous PAP and MPN diagnoses demonstrate the importance of evaluating for GM-CSF autoantibodies to distinguish autoimmune and secondary forms of PAP.

Novel Test For Multiple Myeloma Uses Microchip, Conventional Blood Sample

Novel Test For Multiple Myeloma Uses Microchip, Conventional Blood Sample

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MIT team develops simple, less painful diagnostic test for multiple myeloma using microfluidic chip and conventional blood sample.

Optimal Management of Myeloma With Bortezomib

Optimal Management of Myeloma With Bortezomib

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In this review of the role of bortezomib in the treatment of multiple myeloma, the researchers explain what nurses need to watch for in patients taking this drug.

Protein Suppresses Transformation of Myelodysplastic Syndrome to Acute Myeloid Leukemia

Protein Suppresses Transformation of Myelodysplastic Syndrome to Acute Myeloid Leukemia

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Research on the transformation of MDS to AML identifies a protein whose deletion is a potential tumor suppressor that would block this disease progression.

New Gene Mutations Associated with Erdheim-Chester Disease Could Improve Treatment Options

New Gene Mutations Associated with Erdheim-Chester Disease Could Improve Treatment Options

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BRAF other MAPK pathway gene mutations associated with Erdheim-Chester disease reveal that ECD is a neoplastic disease.

Psoriasis May Increase Risk of Melanoma and Hematologic Cancers

Psoriasis May Increase Risk of Melanoma and Hematologic Cancers

Patients with psoriasis had 1.53 times greater risk of developing a malignancy, regardless of the type of psoriasis therapy they are receiving.

Letermovir Reduces CMV Infection, Improves Survival After Stem Cell Transplantation

Letermovir Reduces CMV Infection, Improves Survival After Stem Cell Transplantation

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A novel agent, letermovir, reduced incidence of CMV in patients undergoing stem cell transplantation for hematologic malignancies.

Hematologic Oral Chemotherapy Clinic Reduces Emergency Department Visits

Hematologic Oral Chemotherapy Clinic Reduces Emergency Department Visits

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A hematologic multidisciplinary oral chemotherapy clinic established at a community hospital identified adverse events early and reduced ED visits.

Carfilzomib Improves OS vs Bortezomib in R/R Multiple Myeloma

Carfilzomib Improves OS vs Bortezomib in R/R Multiple Myeloma

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Carfilzomib significantly prolonged overall survival compared with bortezomib in patients with relapsed or refractory multiple myeloma.

Earlier and Later Adult BMI Associated With Multiple Myeloma Risk

Earlier and Later Adult BMI Associated With Multiple Myeloma Risk

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Younger and usual adult body mass index (BMI) may be linked to increased risk for developing multiple myeloma, research indicates.

Lenalidomide Maintenance Appears Efficacious for Relapsed DLBCL

Lenalidomide Maintenance Appears Efficacious for Relapsed DLBCL

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Lenalidomide maintenance appears efficacious for relapsed diffuse large B cell lymphoma.

Blood Test Predicts Stem Cell Transplant Success in Myelodysplastic Syndrome

Blood Test Predicts Stem Cell Transplant Success in Myelodysplastic Syndrome

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Blood test combined with medical status information predicts stem cell transplant success in patients with MDS.

Treatment Outcomes Were Unchanged by Brentuximab Vedotin (BV)-induced Peripheral Neuropathy

Treatment Outcomes Were Unchanged by Brentuximab Vedotin (BV)-induced Peripheral Neuropathy

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Patients who were surveyed reported that the benefits of treatment with BV outweighed its risks.

Pembrolizumab Active in Refractory NK/T-cell Lymphoma

Pembrolizumab Active in Refractory NK/T-cell Lymphoma

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PD-1 blockade with pembrolizumab was active and induced durable responses in patients with natural killer (NK)/T-cell lymphoma failing L-asparaginase.

BBD Regimen Efficacious as First-line Therapy for Myeloma

BBD Regimen Efficacious as First-line Therapy for Myeloma

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Bendamustine, bortezomib, and dexamethasone is efficacious and tolerable as first-line therapy for patients with myeloma ineligible to receive high-dose therapy.

Managing Adverse Effects From Oral Kinase Inhibitors in Patients With Hematologic Cancers

Managing Adverse Effects From Oral Kinase Inhibitors in Patients With Hematologic Cancers

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Ibrutinib, idelalisib, ponatinib, and ruxolitinib are each associated with a variety of potential adverse effects and oncology nurses must be aware of these to successfully monitor for them.

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