ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

HECTOROL INJ
Secondary hyperparathyroidism or hypocalcemia
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

HECTOROL INJ Rx

Generic Name and Formulations:
Doxercalciferol 2mcg/mL; soln for IV inj.

Company:
Sanofi Genzyme Company

Therapeutic Use:

Indications for HECTOROL INJ:

Secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on dialysis.

Adult:

Dialysis: 4mcg three times weekly after dialysis; adjust dose to maintain intact parathyroid hormone (iPTH) between 150–300pg/mL. If iPTH is not lowered by 50% and fails to reach target range, may increase by 1–2mcg at 8-week intervals. Max 18mcg/week. If iPTH <100pg/mL, suspend for 1 week, then resume at a dose that is at least 1mcg lower.

Children:

Not established.

Contraindications:

Hypercalcemia. Vit.D toxicity.

Warnings/Precautions:

Maintain appropriate calcium, phosphate, fluid intake. Keep serum calcium times phosphate product (Ca × P) <55 in CKD patients. Monitor iPTH, serum calcium, phosphorus (dialysis: at baseline and weekly thereafter; predialysis: every 2 weeks for 3 months during titration, then monthly for 3 months and every 3 months thereafter). Adjust phosphate binder dose to maintain PTH suppression and serum calcium and phosphate levels. Hepatic impairment. Inj: monitor for hypersensitivity at initiation; discontinue and treat if occurs. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Additive effects and hypercalcemia with concomitant other forms of Vit.D. Hypermagnesemia with magnesium-containing antacids. May be affected by CYP450 inhibitors (eg, ketoconazole, erythromycin) or hepatic enzyme inducers (eg, glutethimide, phenobarbital); dose adjustments may be needed.

See Also:

HECTOROL

Pharmacological Class:

Vit. D analog.

Adverse Reactions:

Edema, headache, malaise, nausea, vomiting, arthralgia, weight increase, dizziness, sleep disorder, dyspnea; Vit.D toxicity (eg, hypercalcemia, hypercalciuria, hyperphosphatemia, adynamic bone diseases, arrhythmias, seizures); see full labeling.

How Supplied:

Caps—50; Single-use vial (1mL, 2mL)—1; Multi-dose vial (2mL)—1

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs