The genetic origins of the invasive pattern of colon cancer metastasis

the ONA take:

Metastasis always denotes aggressive disease and a trend toward poor prognosis. But what if the metastatic process could be anticipated? A team of scientists at the Institute for Research in Barcelona, Spain, identified a molecule that signals staggered colon cancer metastasis in the liver to progress to the lung. Of the patients with colon cancer who develop metastasis, 40% present metastasis to the liver first, then to the lung, and always in this clinical order of appearance. These results have implications for the use of p38 inhibitors in certain patients with advanced stages or colon cancer or established metastasis.

The genetic origins of the invasive pattern of colon cancer metastasis
The genetic origins of the invasive pattern of colon cancer metastasis
The genes that favor staggered colon cancer metastasis have been discovered by researchers. Of the colon cancer patients that develop metastases, 40% present metastasis first to the liver and later to the lung, always in this clinical order of appearance.
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