Tampons containing ovarian tumor cells may help detect cancer
the ONA take:
According to a new study in the journal of Obstetrics & Gynecology, researchers at the University of Virginia in Charlottesville, Virginia, have found tumor DNA in cells trapped in tampons placed in the vaginas of patients with ovarian cancer. For the study, the researchers wanted to determine whether ovarian tumor cells migrate to the vagina, so they enrolled women with ovarian cancer who were about to undergo surgery to remove a pelvic mass.
Of five women with advanced serious ovarian cancer whose fallopian tubes were intact, three women had tumor cells in the tampons with the same TP53 mutation that was found in their tumors. The results suggest that cancer cells do migrate from the ovaries in the upper part of the reproductive tract down into the vagina.
The researchers hope to further develop the test, which utilized a type of DNA sequencing known as deep sequencing, so that they can detect early-stage cancer or precancerous lesions prior to becoming malignant. The researchers plan to expand the study to a larger population of women with ovarian cancer and to make the deep DNA sequencing test more sensitive.
The study suggest that tampons could be used to detect ovarian cancer, but further development and future studies are required.
Tumor DNA in cells trapped in tampons placed in the vaginas of patients with ovarian cancer.
Tampons could one day help doctors spot early-stage ovarian cancer in women at high risk for this deadly disease, a small new study suggests.
In the study, researchers found tumor DNA in cells trapped in ordinary tampons that were placed in the vaginas of ovarian cancer patients.
"In about 60 percent of patients who had their [fallopian] tubes still intact, we were able to pick up tumor cells, or essentially tumor DNA, in the vaginal tract," said Dr. Charles Landen, an associate professor of gynecologic oncology at the University of Virginia in Charlottesville, and one of the study researchers. (Having intact fallopian tubes is important to the findings because the tubes are the conduits that connect the ovaries with the lower parts of the reproductive system, including the uterus and the vagina.)
- Novel Blood Test Detects Cancer, Locates Tumor Without Invasive Procedures
- Cabozantinib Activates Innate Immune Response, Eliminating Prostate Cancer
- Shorter Treatment of Breast Cancer with Trastuzumab May Lead to Improved Results
- Colorectal Cancer Rates Increased Sharply Among Generation X and Millennials
- Pneumonia Associated With Common Cold May Cause Fatal Illness in Stem Cell Transplant Recipients
- Early Palliative Care Reduced ICU Use in Patients With Advanced Cancer
- Ginger Extract Raises Antioxidant Levels in Patients Undergoing Chemotherapy
- Nurse Navigators Improve Physician Engagement in Pretreatment Discussions
- Screening Increases Early Palliative Care, Reduces Aggressive EOL Measures
- Antiperspirants/Deodorants and Breast Cancer (Fact Sheet)
- Risk of Second Cancers Increased in Hodgkin Lymphoma Survivors
- ONS Partners with ASCO CancerLinQ to Launch CancerLinQ® Ambassadors Program
- Characteristics of Clinical Trials and Barriers to Patient Enrollment Identified
- Exercise Improves Coping While Undergoing Chemotherapy for Advanced GI Cancer
- Genetic Similarity to BRCA1/BRCA2 Mutations May Impact Treatment Options
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|